RAB21: A Protein with Potential as A Drug Target (G23011)

Target Name: RAB21

NCBI ID: G23011

Other Name(s): RAB21_HUMAN | KIAA0118 | GTP-binding protein RAB21 | RAB21, member RAS oncogene family | Ras-related protein Rab-21

RAB21: A Protein with Potential as A Drug Target

RAB21 is a protein that is expressed in many tissues throughout the body. It is a member of the Rab gene family, which is known for the production of small GTPases. These proteins play a crucial role in cell signaling and are involved in a wide range of physiological processes, including cell growth, differentiation, and survival.

One of the unique features of RAB21 is its ability to interact with several different proteins, including the protein known as FAK. This protein is known for its role in cell adhesion, and is often involved in the development of cancer. RAB21 has also been shown to interact with the protein known as PDGFR, which is involved in the formation of blood vessels.

In addition to its role in cell signaling, RAB21 is also of interest as a potential drug target. Several studies have shown that inhibiting RAB21 can have a variety of therapeutic effects, including the inhibition of cancer cell growth and the inhibition of the formation of blood vessels. This suggests that RAB21 may be an attractive target for the development of new cancer therapies.

One of the reasons for the potential utility of RAB21 as a drug target is its location in the cell. RAB21 is predominantly expressed in the brain, and is also expressed in other tissues throughout the body, including the heart, the kidneys, and the liver. This suggests that it may be an effective target for drugs that affect a wide range of tissues.

Another potential advantage of RAB21 as a drug target is its stability. Unlike many other proteins, RAB21 is highly stable and is resistant to a wide range of treatments, including many types of cancer. This stability may make it an attractive target for drugs that are designed to be long-lasting and effective.

In conclusion, RAB21 is a protein that is of interest as a potential drug target due to its role in cell signaling and its stability. Further research is needed to fully understand the potential utility of RAB21 as a drug.

Protein Name: RAB21, Member RAS Oncogene Family

Functions: Small GTPase involved in membrane trafficking control (PubMed:18804435, PubMed:25648148). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601)

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