RAD54B: A Non-Coding RNA Molecule Regulating DNA Replication and Cell Apoptosis

Target Name: RAD54B

NCBI ID: G25788

RAD54B: A Non-Coding RNA Molecule Regulating DNA Replication and Cell Apoptosis

RAD54B (RAD54B variant 1) is a non-coding RNA molecule that plays a crucial role in the regulation of DNA replication in eukaryotic cells. It is a key component of the complex protein-DNA binary interface occurs, where DNA replication, and it helps to ensure the faithful transmission of genetic information from one generation to the next. Mutations in the RAD54B gene have been associated with various human diseases, including cancer, neurodegenerative diseases, and developmental disorders.

The RAD54B gene is part of the highly conserved RAD54 gene family, which is characterized by the presence of a single exon and a single intron in the 5' region, as well as a conserved 3' region. The RAD54B gene is expressed in various tissues and cells of the body, including the brain, heart, liver, and cervical tissue, and its expression level can vary depending on the cell type and the specific physiological state of the organism.

Mutations in the RAD54B gene have been implicated in the development and progression of various diseases, including cancer, neurodegenerative diseases, and developmental disorders. For example, studies have shown that RAD54B mutations are frequently observed in colorectal cancer and other gastrointestinal cancers, and that these these mutations can lead to the development of resistance to chemotherapy.

In addition to its role in cancer, RAD54B is also a potential drug target. The RAD54B protein has been shown to play a role in the regulation of DNA replication, which makes it a potential target for small molecules that can inhibit DNA replication in cancer cells . Additionally, the RAD54B gene has been shown to be involved in the regulation of cell apoptosis, which is a process by which cells undergo programmed cell death. This suggests that RAD54B may also be a potential target for drugs that promote cell apoptosis in cancer cells.

Expression and function of RAD54B

RAD54B is a non-coding RNA molecule that is expressed in various tissues and cells of the body. It is primarily expressed in the nucleus of eukaryotic cells and is involved in the regulation of DNA replication. RAD54B is a key component of the complex protein- DNA binary interface, where DNA replication occurs. It helps to ensure the faithful transmission of genetic information from one generation to the next by regulating the formation of double-stranded DNA bonds during DNA replication.

RAD54B is a 14.8 kb RNA molecule that contains 119 unique amino acid residues. It has a calculated molecular mass of 17.9 kDa and a predicted pI of 5.9. RAD54B is highly conserved, with only a single amino acid residue being found to be significantly different between the amino acid sequences of RAD54B and RAD51, which is a related gene that is also involved in the regulation of DNA replication.

In addition to its role in DNA replication, RAD54B is also involved in the regulation of cell apoptosis. Cell apoptosis is a process by which cells undergo programmed cell death, which is a critical mechanism for the regulation of tissue homeostasis and the rejection of foreign particles and mutations. RAD54B is involved in the regulation of cell apoptosis by promoting the formation of double-stranded DNA bonds during DNA replication.

The formation of double-stranded DNA bonds during DNA replication is a critical step in the regulation of cell apoptosis. Double-stranded DNA bonds are formed by the synthesis of a new complementary strand of DNA from the template strand. This process requires the assistance of DNA polymerase, which is a complex protein that

Protein Name: RAD54 Homolog B

Functions: Involved in DNA repair and mitotic recombination. May play an active role in recombination processes in concert with other members of the RAD52 epistasis group

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