GLUL: Enzyme Involved in Brain Function and Drug Target (G2752)

Target Name: GLUL

NCBI ID: G2752

GLUL: Enzyme Involved in Brain Function and Drug Target

GLUL (Glutamate Decarboxylase) is an enzyme that is involved in the breakdown of glutamate, a key signaling molecule in the brain. Glutamate is produced by the body and is found in many foods, including muscle, fish, and beans. It is also produced by certain bacteria that live in the gut.

The role of GLUL in the body is to break down glutamate and release the amino acid glutamic acid. Glutamic acid is then used to transmit signals in the brain, particularly in the nervous system. It is also involved in the regulation of many different bodily functions , including muscle movement, appetite, and sleep.

GLUL is a protein that is expressed in many different tissues throughout the body, including the brain, muscle, and liver. It is primarily localized to the brain, where it is involved in the production of glutamate. GLUL is a critical enzyme that is involved in the breakdown of glutamate, which is essential for the normal functioning of the brain.

One of the key functions of GLUL is its role in the production of glutamate from the amino acid L-glutamic acid. L-glutamic acid is an essential amino acid that is found in many foods, including muscle, fish, and beans. It is also produced by certain bacteria that live in the gut.

GLUL is involved in the breakdown of L-glutamic acid and the production of glutamate. When GLUL is activated, it breaks down L-glutamic acid and releases the amino acid glutamate. Glutamate is then used to transmit signals in the brain and is involved in many different physiological processes, including muscle movement, appetite, and sleep.

GLUL is also involved in the regulation of the levels of glutamate in the brain. It helps to maintain a stable level of glutamate in the brain, which is important for the normal functioning of the nervous system. GLUL also plays a role in the regulation of the levels of other amino acids, which are also important for the normal functioning of the brain.

In addition to its role in the production and regulation of glutamate, GLUL is also involved in the regulation of many different cellular processes in the brain. It is a target for many different signaling molecules, including neurotransmitters and hormones.

GLUL is also involved in the production of other important molecules in the brain, including the neurotransmitter serotonin. Serotonin is involved in the regulation of many different physiological processes, including mood, appetite, and sleep. GLUL is also involved in the production of other neurotransmitters , including dopamine and GABA.

GLUL is a critical enzyme that is involved in the breakdown of glutamate and the production of other important molecules in the brain. It is a potential drug target and could be used to treat a variety of neurological and psychiatric disorders.

Protein Name: Glutamate-ammonia Ligase

Functions: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:30158707, PubMed:16267323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Essential for proliferation of fetal skin fibroblasts (PubMed:18662667). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development: acts by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (PubMed:30158707). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (PubMed:30158707). Plays a role in ribosomal 40S subunit biogenesis (PubMed:26711351)

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