Target Name: TERB1
NCBI ID: G283847
Other Name(s): telomere repeat binding bouquet formation protein 1 | coiled-coil domain-containing protein 79 | Telomere repeats-binding bouquet formation protein 1 | SPGF60 | Coiled-coil domain-containing protein 79 | TERB1_HUMAN | CCDC79 | Telomere repeat binding bouquet formation protein 1

Unlocking the Potential of TERB1: A Potential Drug Target and Biomarker

Introduction

Telomeres are repetitive DNA sequences that protect the ends of chromosomes from degradation, fusion, and other forms of damage. As we age, telomeres shorten, leading to the eventual loss of cellular immortality. The telomere repeat binding bouquet formation protein 1 (TERB1) is a protein that helps maintain the integrity of telomeres. In this article, we will explore the potential of TERB1 as a drug target and biomarker.

The Importance of Telomeres

Telomeres are critical for the survival of cells and organisms. As telomeres shorten, the ends of chromosomes become more susceptible to damage from the environment, including radiation, UV radiation, and other forms of stress. When telomeres become too short, a cell may undergo a program of cell division, leading to the development of cancer.

Maintaining Telomere Integrity

TERB1 is a protein that helps maintain the integrity of telomeres. It does this by forming a specific arrangement of DNA sequences at the ends of telomeres. This arrangement creates a \"bouquet\" of DNA that can help protect the ends of telomeres from degradation and fusion.

Drug Target Potential

The potential of TERB1 as a drug target is high due to its unique mechanism of action. As telomeres shorten, TERB1 helps to prevent the formation of a \"short-telomere syndrome\" that can lead to the loss of cellular immortality. This suggests that TERB1 could be an effective target for therapies aimed at extending the lifespan of cells.

In addition, TERB1 has been shown to play a key role in the regulation of cell cycle progression. Its expression is highly dependent on the telomere length, which suggests that it may be a useful biomarker for tracking the effectiveness of certain therapies.

Biomarker Potential

The potential of TERB1 as a biomarker is high due to its unique expression patterns. TERB1 is primarily expressed in the nuclei of HeLa cells, and its levels increase as the telomeres become shorter. This suggests that TERB1 may be an effective biomarker for tracking the effectiveness of therapies aimed at extending telomeres.

In addition, TERB1 has been shown to play a key role in the regulation of cell cycle progression and apoptosis. Its expression is highly dependent on the telomere length, which suggests that it may be an effective biomarker for tracking the effectiveness of therapies aimed at preventing the loss of cellular immortality.

Conclusion

In conclusion, TERB1 is a protein that plays a critical role in the regulation of telomere integrity. Its expression is highly dependent on telomere length, which suggests that it may be an effective target for therapies aimed at extending the lifespan of cells. In addition, TERB1 has been shown to play a key role in the regulation of cell cycle progression and apoptosis, which suggests that it may be an effective biomarker for tracking the effectiveness of therapies aimed at preventing the loss of cellular immortality.

The potential of TERB1 as a drug target and biomarker is high. Further research is needed to fully understand its unique mechanism of action and its potential as a therapeutic target.

Protein Name: Telomere Repeat Binding Bouquet Formation Protein 1

Functions: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the MAJIN-TERB1-TERB2 complex, TERB1 probably mediates association with the shelterin/telosome complex via interaction with TERF1, promoting priming telomeric DNA attachment'. Promotes telomere association with the nuclear envelope and deposition of the SUN-KASH/LINC complex. Also recruits cohesin to telomeres to develop structural rigidity

More Common Targets

TERB2 | TERC | TERF1 | TERF1P3 | TERF2 | TERF2IP | TERLR1 | TERT | TES | TESC | TESK1 | TESK2 | TESMIN | TESPA1 | TET1 | TET2 | TET2-AS1 | TET3 | Tetraspanin | TEX10 | TEX101 | TEX11 | TEX12 | TEX13A | TEX13B | TEX13C | TEX14 | TEX15 | TEX19 | TEX2 | TEX21P | TEX22 | TEX26 | TEX261 | TEX264 | TEX28 | TEX29 | TEX30 | TEX33 | TEX35 | TEX36 | TEX36-AS1 | TEX37 | TEX38 | TEX41 | TEX43 | TEX44 | TEX45 | TEX46 | TEX47 | TEX48 | TEX49 | TEX50 | TEX52 | TEX53 | TEX55 | TEX56P | TEX9 | TF | TFAM | TFAMP1 | TFAP2A | TFAP2A-AS1 | TFAP2A-AS2 | TFAP2B | TFAP2C | TFAP2D | TFAP2E | TFAP4 | TFB1M | TFB2M | TFCP2 | TFCP2L1 | TFDP1 | TFDP1P2 | TFDP2 | TFDP3 | TFE3 | TFEB | TFEC | TFF1 | TFF2 | TFF3 | TFG | TFIID Basal Transcription Factor Complex | TFIIIC2 complex | TFIP11 | TFIP11-DT | TFPI | TFPI2 | TFPT | TFR2 | TFRC | TG | TGDS | TGFA | TGFA-IT1 | TGFB1 | TGFB1I1 | TGFB2