IL-3: Promoting Immune Cell Differentiation and Function (G28413)

Target Name: IGHV3-65

NCBI ID: G28413

Other Name(s): 3-65P | IGHV365 | Immunoglobulin heavy variable 3-65 (pseudogene) | immunoglobulin heavy variable 3-65 (pseudogene)

IL-3: Promoting Immune Cell Differentiation and Function

IGHV3-65 (3-65 polyiodine), also known as human interleukin-gene 3 (IL-3), is a cytokine that plays a crucial role in the development and maintenance of the normal function of various cells in the immune system. IL-3 is expressed in a variety of immune cells, including T cells, B cells, macrophages and dendritic cells. The biological effects of IL-3 include promoting and regulating the differentiation and function of immune cells, thereby playing an important immunoregulatory role in the immune system.

The molecular structure of IL-3 is a single-stranded DNA molecule consisting of 114 amino acids. The IL-3 gene is located on human chromosome 11q34. The expression level of IL-3 can be detected by a variety of methods, including ELISA, Western blot, and flow cytometry.

The biological role of IL-3 is mainly reflected in promoting and regulating the differentiation and function of immune cells. In the immune system, IL-3 helps promote the development and maturation of T cells and enhances the activity and stability of T cells. IL-3 can also promote the activation and proliferation of B cells, thereby increasing their ability to produce antibodies. In addition, IL-3 can also promote the activation and function of macrophages and dendritic cells, thereby enhancing the immune system's ability to clear pathogens.

The biological role of IL-3 is also reflected in regulating the balance of the immune system. Under normal circumstances, the immune system maintains a balanced state, that is, the number and function of immune cells are relatively stable. IL-3 can regulate this balance and keep the immune system in a relatively stable state. When the immune system is stimulated, IL-3 can promote the differentiation and proliferation of immune cells, thereby enhancing the immune system's response ability. When the immune system is in an over-activated state, IL-3 can inhibit the activity of immune cells, thereby reducing the excessive immune response.

The biological role of IL-3 is also reflected in its influence on the growth and metastasis of tumor cells. Studies have shown that IL-3 can promote the growth and metastasis of tumor cells. The expression level of IL-3 is positively correlated with the growth and metastasis ability of tumor cells, so IL-3 can serve as a tumor

Protein Name: Immunoglobulin Heavy Variable 3-65 (pseudogene)

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