Target Name: APC
NCBI ID: G324
Other Name(s): APC variant 15 | APC variant 1 | GS | Protein APC | Adenomatous polyposis coli protein (isoform a) | APC regulator of WNT signaling pathway, transcript variant 4 | APC variant 4 | APC regulator of WNT signaling pathway, transcript variant 13 | APC variant 10 | Deleted in polyposis 2.5 | APC regulator of WNT signaling pathway, transcript variant 15 | Adenomatous polyposis coli protein | APC regulator of WNT signaling pathway, transcript variant 3 | Adenomatous polyposis coli protein isoform h | epididymis secretory sperm binding protein | DESMD | Adenomatosis polyposis coli | APC variant 2 | Epididymis secretory sperm binding protein | APC variant 3 | APC regulator of WNT signaling pathway, transcript variant 9 | APC variant 7 | Adenomatous polyposis coli protein isoform e | APC regulator of WNT signaling pathway, transcript variant 10 | protein phosphatase 1, regulatory subunit 46 | Adenomatous polyposis coli protein (isoform b) | adenomatous polyposis coli (APC) | Adenomatous polyposis coli protein isoform b | Adenomatous polyposis coli protein isoform k | APC regulator of WNT signaling pathway, transcript variant 1 | Adenomatosis polyposis coli tumor suppressor | DP2 | truncated adenomatosis polyposis coli | DP3 | FPC | adenomatosis polyposis coli tumor suppressor | FAP | APC regulator of WNT signaling pathway, transcript variant 7 | Adenomatous polyposis coli protein isoform m | APC, WNT signaling pathway regulator | DP2.5 | APC regulator of WNT signaling pathway | deleted in polyposis 2.5 | PPP1R46 | APC variant 13 | APC regulator of WNT signaling pathway, transcript variant 2 | BTPS2 | APC_HUMAN | Protein phosphatase 1, regulatory subunit 46 | APC variant 9 | WNT signaling pathway regulator | Truncated adenomatosis polyposis coli | Adenomatous polyposis coli (APC) | Adenomatous polyposis coli protein isoform g

APC: A Protein Implicated in Cancer Development

APC (APC variant 15) is a protein that is expressed in the human placenta and has been shown to play a role in the development and maintenance of cancer. The protein is derived from the APC gene, which is located on chromosome 16.

The APC gene was first identified in the 1990s as a potential cancer-related gene. Studies have since shown that APC is involved in the development of many types of cancer, including breast, ovarian, and prostate cancer.

One of the key functions of APC is its role in cell signaling. The protein is a transcription factor, which means that it helps to turn on the genes of cells. In cancer cells, APC can promote the growth and survival of cells that have been mutated or altered in ways that are associated with cancer.

Another function of APC is its role in the development of cancer stem cells. Cancer stem cells are cells that have the ability to develop into any type of cancer cell. Studies have shown that APC helps to maintain the stem-like properties of cancer cells, which allows them to evade attempts to undergo programmed cell death.

In addition to its role in cancer development, APC has also been shown to be involved in the regulation of implantation. When a fertilized egg implants in the uterus, APC helps to ensure that the egg is able to successfully implant and begin to divide.

Despite its potential as a cancer target, APC has not yet been approved for use in any FDA-approved treatments. Further research is needed to better understand the role of APC in cancer development and to identify potential strategies for targeting the protein in order to develop more effective treatments for cancer.

In conclusion, APC (APC variant 15) is a protein that has been shown to be involved in the development and maintenance of cancer. Further research is needed to better understand the role of the protein in cancer development and to identify potential strategies for targeting it in order to develop more effective treatments for cancer.

Protein Name: APC Regulator Of WNT Signaling Pathway

Functions: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization

More Common Targets

APC2 | APCDD1 | APCDD1L | APCDD1L-DT | APCS | APEH | APELA | APEX1 | APEX2 | APH1A | APH1B | API5 | APIP | APLF | APLN | APLNR | APLP1 | APLP2 | APMAP | APOA1 | APOA1-AS | APOA2 | APOA4 | APOA5 | APOB | APOBEC1 | APOBEC2 | APOBEC3A | APOBEC3A_B | APOBEC3B | APOBEC3B-AS1 | APOBEC3C | APOBEC3D | APOBEC3F | APOBEC3G | APOBEC3H | APOBEC4 | APOBR | APOC1 | APOC1P1 | APOC2 | APOC3 | APOC4 | APOC4-APOC2 | APOD | APOE | APOF | APOH | APOL1 | APOL2 | APOL3 | APOL4 | APOL5 | APOL6 | APOLD1 | Apolipoprotein B mRNA editing complex | APOM | APOO | APOOL | APOOP2 | APOOP5 | APP | APPAT | APPBP2 | APPL1 | APPL2 | APRG1 | APRT | APTR | APTX | AQP1 | AQP10 | AQP11 | AQP12A | AQP12B | AQP2 | AQP3 | AQP4 | AQP4-AS1 | AQP5 | AQP6 | AQP7 | AQP7P1 | AQP7P2 | AQP7P3 | AQP7P5 | AQP8 | AQP9 | AQR | AR | ARAF | ARAP1 | ARAP1-AS2 | ARAP2 | ARAP3 | ARC | ARCN1 | AREG | AREL1 | ARF1