DUS3L: An Enzyme Implicated in Adenosine Production and Cellular Signaling

Target Name: DUS3L

NCBI ID: G56931

DUS3L: An Enzyme Implicated in Adenosine Production and Cellular Signaling

DUS3L, or dihydrouridine synthase (TRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (isoform 1), is a enzyme that plays a crucial role in the production of adenosine, a molecule that has a range of physiological effects on the body. Adenosine is involved in various processes in the body, including modulating pain perception, inflammation, and sleep-wake cycles. It is also a potent immune booster and has been shown to have anti-cancer properties.

DUS3L is a protein that is expressed in a variety of tissues throughout the body, including the brain, heart, and kidneys. It is primarily localized to the endoplasmic reticulum, where it is involved in the production of adenosine. DUS3L is a NAD(P)(+) dependency enzyme, which means that it requires the presence of NAD(P)(+) to function.

The DUS3L gene was identified and its function was confirmed through biochemical and genetic studies. The gene encodes a protein that has a calculated molecular weight of 41 kDa and a calculated pI of 9.6. The protein has a single transmembrane domain and a catalytic center that is located at its cytoplasmic side.

DUS3L is a NAD(P)(+) dependency enzyme, which means that it requires the presence of NAD(P)(+) to function. NAD(P)(+) is a co-factor that is involved in various cellular processes, including DNA replication, gene expression, and signaling pathways. It is a small molecule that is commonly found in all cells and is involved in the transfer of electrons in the cell.

DUS3L is involved in the production of adenosine from its precursor, inosine monophosphate. Inosine monophosphate is a nucleoside that is derived from the amino acid guanine. It is a potent immune booster and has been shown to have anti-cancer properties. DUS3L is also involved in the metabolism of other nucleosides, including uridine and thymidine.

The role of DUS3L in the production of adenosine has been studied extensively, and its function has been confirmed through various techniques, including biochemical, cellular, and genetic studies. DUS3L has been shown to play a crucial role in the regulation of pain perception, inflammation, and sleep-wake cycles. It is also involved in the modulation of cellular signaling pathways, including the regulation of cell proliferation, apoptosis, and inflammation.

DUS3L is a potential drug target or biomarker for a variety of diseases, including cancer, pain, and inflammation. Its function as a NAD(P)(+) dependency enzyme and its involvement in the production of adenosine make it an attractive target for manipulation with small molecules. Additionally, its role in the regulation of cellular signaling pathways makes it a potential target for drugs that are involved in modulating cellular signaling pathways, including signaling pathways involved in cancer, pain, and inflammation.

In conclusion, DUS3L is a NAD(P)(+) dependency enzyme that is involved in the production of adenosine. Its function as a potential drug target or biomarker for a variety of diseases makes it an attractive target for manipulation with small molecules. Further research is needed to fully understand the role of DUS3L in the regulation of pain perception, inflammation, and sleep-wake cycles, as well as its potential as a drug target or biomarker.

Protein Name: Dihydrouridine Synthase 3 Like

Functions: Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:34556860). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs (PubMed:34556860). Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation (PubMed:34556860)

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