RPE65: Potential Drug Target and Biomarker (G6121)

Target Name: RPE65

NCBI ID: G6121

RPE65: Potential Drug Target and Biomarker

RPE65 (short for solute transport protein 65), is a protein that plays a crucial role in the regulation of an essential process in the body called transport. This process is responsible for moving essential nutrients such as oxygen and nutrients throughout the body. It is a member of the superfamily of transport proteins, known as the carrier proteins, and is found in most organisms, including humans.

Recent studies have suggested that RPE65 may have potential as a drug target or biomarker. This is because the regulation of solute transport is a critical function for many physiological processes in the body, including cell survival, growth, and reproduction. Therefore, any molecules that can modulate this process could be of great interest to scientists.

Drug Target Potential

One of the main reasons for the potential drug target status of RPE65 is its role in the regulation of an essential process that is required for the survival of many cell types. The regulation of solute transport is critical for the delivery of oxygen and nutrients to cells , which are essential for their survival and growth.

Additionally, the regulation of solute transport is also involved in the regulation of ion and water balance, which are critical for maintaining the stability of the cell. This is important for maintaining the pH balance, which is critical for the regulation of many cellular processes.

Another potential drug target for RPE65 is its role in the regulation of cell death. Studies have shown that RPE65 is involved in the regulation of cell death, and that its levels are often reduced in diseases such as cancer, neurodegenerative diseases, and cardiovascular diseases. Therefore, targeting RPE65 may be a promising strategy for the development of new treatments for these diseases.

Biomarker Potential

In addition to its potential as a drug target, RPE65 may also be a useful biomarker for the diagnosis and monitoring of certain diseases. For example, RPE65 has been shown to be expressed in a variety of tissues and cells, including brain, heart, and liver. This makes it a potential biomarker for a variety of diseases, including neurodegenerative diseases, cardiovascular diseases, and cancer.

One of the key advantages of RPE65 as a biomarker is its stability and expression in different tissues and cells. This stability is important for the development of diagnostic tests that are based on the expression of RPE65, as these tests can be used to monitor disease progression and assess the effectiveness of treatments.

Conclusion

In conclusion, RPE65 is a protein that plays a crucial role in the regulation of solute transport, which is an essential process for the survival and growth of many cells. The regulation of solute transport is also involved in the regulation of cell death, which makes it a potential drug target. Additionally, RPE65 may also be a useful biomarker for the diagnosis and monitoring of certain diseases.

Future research in the field of RPE65 may focus on the development of new treatments for diseases that are characterized by the regulation of solute transport. Additionally, further studies are needed to determine the role of RPE65 as a biomarker for the diagnosis and monitoring of certain diseases. .

Protein Name: Retinoid Isomerohydrolase RPE65

Functions: Critical isomerohydrolase in the retinoid cycle involved in regeneration of 11-cis-retinal, the chromophore of rod and cone opsins. Catalyzes the cleavage and isomerization of all-trans-retinyl fatty acid esters to 11-cis-retinol which is further oxidized by 11-cis retinol dehydrogenase to 11-cis-retinal for use as visual chromophore (PubMed:16116091). Essential for the production of 11-cis retinal for both rod and cone photoreceptors (PubMed:17848510). Also capable of catalyzing the isomerization of lutein to meso-zeaxanthin an eye-specific carotenoid (PubMed:28874556). The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT (By similarity)

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