Potential Drug Target and Biomarker LOC650157: Unlocking The Switch for CTIA-Like Enzyme
Potential Drug Target and Biomarker LOC650157: Unlocking The Switch for CTIA-Like Enzyme
Exploring the Potential Drug Target and Biomarker LOC650157: Unlocking the Switch for Peptidyl-Prolyl Cis-Trans Isomerase A-Like
Introduction
The discovery of new protein-protein interactions and their role in various biological processes has significantly impacted our understanding of the complexity of biological systems. One such interaction that has garnered significant attention in recent years is the cis-trans isomerase A-like (CTIA- like) enzyme, located within the LOC650157 gene. This enzyme is responsible for the catalytic conversion of two amino acids, prolyl and peptidyl, into their cis and trans isomers, respectively. As such, it plays a critical role in the regulation of protein structure and function, and is of great interest to researchers as potential drug targets or biomarkers.
The Protein-Protein Interaction
The cis-trans isomerase A-like (CTIA-like) enzyme is a member of the A-type heme family, which are characterized by a conserved active site and a variable subunit (尾2). This enzyme's active site is residue 650, which is a crucial site for catalytic activity, as it plays a key role in the substrate binding and activation.
The interaction between CTIA-like and its substrate, prolyl and peptidyl, is a critical aspect of its function. Prolyl is a highly conserved amino acid that is involved in various cellular processes, including DNA replication, gene expression, and inflammation. Peptidyl, on the other hand, is an emerging target for therapeutic intervention, with recent studies suggesting that it may play a role in various neurodegenerative diseases.
The Role of CTIA-like in Protein Structure and Function
The cis-trans isomerase A-like (CTIA-like) enzyme is involved in the regulation of protein structure and function, as well as the conversion of prolyl and peptidyl amino acids into their cis and trans isomers, respectively. This process is critical for the formation of specific protein structures, which in turn influence various cellular functions.
The interaction between CTIA-like and its substrate, prolyl and peptidyl, is a crucial aspect of its function. Prolyl is a highly conserved amino acid that is involved in various cellular processes, including DNA replication, gene expression, and inflammation. Peptidyl, on the other hand, is an emerging target for therapeutic intervention, with recent studies suggesting that it may play a role in various neurodegenerative diseases.
The Potential Role of CTIA-like as a Drug Target
The potential of CTIA-like as a drug target is of great interest to researchers, as its unique catalytic activity and subunit specificity make it an attractive target for small molecules. Several studies have investigated the efficacy of various small molecules as CTIA-like inhibitors, with some showing promise in modulating cellular functions and others displaying no activity.
One of the most promising small molecules is N-[4-(2-methylpropyl)amino]-4-[(2-methylpropyl) amino]-7-nitro-2,1,3-benzoxadiazole (NIPA), which is a potent inhibitor of CTIA-like with a binding constant (Ki) of 13 nM. NIPA has been shown to inhibit the activity of both wild-type and mutant CTIA-like enzymes, and has been shown to protect against the neurotoxicity associated with various proteins misfolding diseases.
Another promising small molecule is 尾-[(2-methylpropyl) amino]-4-[(2-methylpropyl) amino]-5-nitro-2,1,3-benzoxadiazole (MN-尾), which has a Ki of 11 nM and has been shown to inhibit the activity of both wild-type and mutant CTIA
Protein Name: Peptidyl-prolyl Cis-trans Isomerase A-like
More Common Targets
LOC650226 | LOC651536 | LOC652276 | LOC652608 | LOC653303 | LOC653503 | LOC653513 | LOC653631 | LOC653653 | LOC653698 | LOC727751 | LOC728024 | LOC728098 | LOC728114 | LOC728138 | LOC728376 | LOC728392 | LOC728417 | LOC728485 | LOC728554 | LOC728660 | LOC728688 | LOC728715 | LOC728739 | LOC728743 | LOC728877 | LOC728989 | LOC729086 | LOC729164 | LOC729173 | LOC729218 | LOC729296 | LOC729444 | LOC729609 | LOC729683 | LOC729732 | LOC729737 | LOC729815 | LOC729870 | LOC729887 | LOC729966 | LOC729973 | LOC730098 | LOC730100 | LOC730101 | LOC730183 | LOC730234 | LOC730338 | LOC730668 | LOC90246 | LOC91450 | LOC93429 | LOC93463 | LOC93622 | LOH12CR2 | Long intergenic non-protein coding RNA 1336 | Long intergenic non-protein coding RNA 205 | Long intergenic non-protein coding RNA 266-4, pseudogene | Long-chain-fatty-acid--CoA ligase | LONP1 | LONP2 | LONRF1 | LONRF2 | LONRF3 | LORICRIN | LOX | LOXHD1 | LOXL1 | LOXL1-AS1 | LOXL2 | LOXL3 | LOXL4 | LPA | LPAL2 | LPAR1 | LPAR2 | LPAR3 | LPAR4 | LPAR5 | LPAR6 | LPCAT1 | LPCAT2 | LPCAT3 | LPCAT4 | LPGAT1 | LPIN1 | LPIN2 | LPIN3 | LPL | LPO | LPP | LPP-AS1 | LPP-AS2 | LPXN | LRAT | LRATD1 | LRATD2 | LRBA | LRCH1 | LRCH2
