BMP4: Unlocking The Potential of Tissue Regeneration (G652)

Target Name: BMP4

NCBI ID: G652

BMP4: Unlocking The Potential of Tissue Regeneration

Bone morphogenetic protein 4 (BMP4) is a protein that plays a crucial role in the development and maintenance of tissues in the body. It is a transmembrane glycoprotein that belongs to the family of morphogenetic proteins, which are involved in the process of cell division and tissue regeneration. BMP4 is one of the four isoforms of BMP4, which include BMP4-1, BMP4-2, BMP4-3, and BMP4-4.

BMP4 is involved in many different processes in the body, including cell proliferation, differentiation, and migration. It is a potent regulator of cell behavior, and is involved in the development and maintenance of tissues such as bones, skin, and heart. It is also involved in the regulation of inflammation and fibrosis.

One of the key functions of BMP4 is its ability to stimulate the production of new cells in the body. This is achieved through the production of growth factors, such as platelet-derived growth factor (PDGF), which can stimulate the production of matrix cells, including bone cells. This is important for the development and maintenance of tissues such as bones, which are critical for support and mobility.

BMP4 is also involved in the regulation of cell migration. This is achieved through the production of chemotactic factors, which can attract cells to specific locations in the body. This is important for the development and maintenance of tissues such as tissues and organs, which are critical for proper function.

BMP4 is also involved in the regulation of cell proliferation and differentiation. This is achieved through the production of signaling molecules, which can regulate the activity of cells. This is important for the development and maintenance of tissues such as muscles, bones, and skin, which are critical for movement and support.

BMP4 is also involved in the regulation of inflammation and fibrosis. This is achieved through the production of pro-inflammatory and pro-fibrotic molecules, which can contribute to the development and progression of diseases such as cancer and fibrosis. This is important for the regulation of tissue repair and regeneration.

Despite its many important functions, BMP4 is still an untargeted drug. There are no known drugs that specifically target BMP4, and there is a need for further research to determine the potential benefits and risks of using BMP4 as a drug. However, BMP4 is an attractive target for research because of its involvement in the development and maintenance of tissues in the body. Further research is needed to determine the potential benefits and risks of using BMP4 as a drug.

Protein Name: Bone Morphogenetic Protein 4

Functions: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (PubMed:31363885). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:25868050, PubMed:8006002). Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:25868050, PubMed:29212066). Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades (PubMed:31363885). For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (PubMed:31363885)

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