FAM166B4: Potential Cancer and Angiogenesis Targets (G730112)

Target Name: FAM166B

NCBI ID: G730112

FAM166B4: Potential Cancer and Angiogenesis Targets

The FAM166B gene, located on chromosome 16, is a member of the family of gene encoding the B protein. The B protein is a key regulator of cell growth, development, and survival, and is involved in a wide range of physiological processes, including cell adhesion, migration, and invasion.

Transcript variants of the FAM166B gene have been identified, and one of them, FAM166B4, has been shown to be a potential drug target or biomarker. The FAM166B4 protein has been shown to interact with several protein partners, including the transcription factor, p53.

The p53 protein is a well-known regulator of gene expression that plays a critical role in the control of cell growth and division. It is also a key factor in the regulation of apoptosis, which is a normal process for the elimination of damaged or dysfunctional cells.

Research has shown that the FAM166B4 protein can inhibit the activity of p53, leading to the activation of cell division and the growth of cancer cells. This suggests that the FAM166B4 protein may be a useful target for cancer treatment.

Another potential mechanism by which the FAM166B4 protein may be involved in cancer is its role in the regulation of angiogenesis, the process by which new blood vessels are formed in tumors. Angiogenesis is a critical process for the development and maintenance of cancer, and it is often associated with poor prognosis.

Research has shown that the FAM166B4 protein is involved in the regulation of angiogenesis, and that it can inhibit the formation of new blood vessels in tumors. This suggests that the FAM166B4 protein may be a useful target for cancer treatment.

In addition to its potential role in cancer, the FAM166B4 protein may also be involved in the regulation of normal cellular processes. For example, it has been shown to be involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs.

The FAM166B4 protein has also been shown to be involved in the regulation of cell migration, which is the process by which cells move from one location to another in the body. This is important for the development and maintenance of tissues and organs, and is often disrupted in cancer.

In conclusion, the FAM166B gene is a member of a family of genes that encode the B protein. The FAM166B4 protein has been shown to interact with the transcription factor, p53, and to inhibit its activity. This suggests that the FAM166B4 protein may be a useful drug target or biomarker for cancer treatment. Furthermore, the FAM166B4 protein has also been shown to be involved in the regulation of cell adhesion, migration and angiogenesis, which are important processes for the development and maintenance of tissues and organs. Further studies are needed to confirm these potential roles and to explore the clinical applications of the FAM166B4 protein.

Protein Name: Family With Sequence Similarity 166 Member B

Functions: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating

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