XRCC2: A Potential Drug Target and Biomarker for X-ray Repair Complementing Defective Repair in Chinese Hamster Cells

Target Name: XRCC2

NCBI ID: G7516

XRCC2: A Potential Drug Target and Biomarker for X-ray Repair Complementing Defective Repair in Chinese Hamster Cells

X-ray exposure can cause damage to DNA, leading to the development of DNA repair deficiencies. Chinese hamster cells (CHCs) are commonly used in research as they have a similar genetic makeup to human cells and can be used to study the effects of drugs on DNA repair. One of the most significant challenges in DNA repair is the repair compensation system, which is not always reliable or efficient. XRCC2, a gene that encodes a protein involved in the repair of x-ray-induced DNA damage in CHCs, has been identified as a potential drug target or biomarker for x-ray repair complementing defective repair in CHCs.

The XRCC2 functions as a part of the non-coding RNA-mediated repair response, which includes homologous recombination, an error-prone repair pathway that can repair up to three-quarters of the DNA double-strand breaks caused by x-rays. protein functions as a critical regulator of this repair pathway, ensuring that the repair response is efficient and accurate.

Studies have shown that XRCC2 plays a crucial role in the repair of DNA double-strand breaks in CHCs. When CHCs are exposed to x-rays, the repair response is activated, and XRCC2 is involved in the evaluation of the damage caused by the x -rays. XRCC2 helps to ensure that the repair response is prompt, accurate, and efficient, leading to the rapid recovery of the DNA double-strand breaks.

In addition to its role in the repair response, XRCC2 has also been shown to be involved in the regulation of cell cycle progression. CHCs are known for their rapid and efficient cell cycle progression, and XRCC2 is involved in the regulation of the S-phase of the cell cycle, which is critical for the completion of DNA replication and repair.

XRCC2 has also been shown to be involved in the regulation of apoptosis, a critical process in cell death and repair. CHCs are known for their ability to undergo apoptosis in response to various stimuli, including x-rays. apoptosis, ensuring that the apoptosis response is prompt and accurate, and that the cell is able to undergo programmed cell death.

In conclusion, XRCC2 is a gene that is involved in the repair of DNA double-strand breaks in CHCs. Its role in the repair response and cell cycle progression makes it a potential drug target or biomarker for x-ray repair complementing defective repair in CHCs . Further studies are needed to determine the exact role of XRCC2 in the repair response and to explore its potential as a drug target or biomarker.

Protein Name: X-ray Repair Cross Complementing 2

Functions: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA

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