LRRC8C: A Potential Drug Target (G84230)

Target Name: LRRC8C

NCBI ID: G84230

LRRC8C: A Potential Drug Target

LRRC8C (FAD158) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the long non-coding RNA (lncRNA) family, which includes around 200,000 known lncRNAs in humans. LRRC8C has been shown to play a role in various biological processes, including cell signaling, DNA replication, and chromatin remodeling.

One of the most promising aspects of LRRC8C is its potential as a drug target. LRRC8C has been shown to interact with a variety of protein substrates, including casein kinase 2 (CK-2), which is a protein that is involved in cell signaling and metabolism. CK-2 is a protein that has been targeted by a number of drugs, including some anti-cancer drugs, and there is interest in using LRRC8C as a potential antagonist of CK-2.

LRRC8C has also been shown to interact with the protein p16INK4a. p16INK4a is a tumor suppressor protein that is involved in the regulation of cell growth and division. LRRC8C has been shown to play a role in the regulation of p16INK4a, which suggests that it may be a useful target for therapies that are aimed at inhibiting cancer growth.

In addition to its potential as a drug target, LRRC8C has also been shown to be involved in a number of biological processes that are important for human health. For example, LRRC8C has been shown to play a role in the regulation of cell death, which is an important process for the maintenance of tissue homeostasis and the elimination of damaged or dysfunctional cells.

LRRC8C has also been shown to be involved in the regulation of inflammation, which is an important process for maintaining the immune system and protecting against infection. In addition, LRRC8C has been shown to play a role in the regulation of cell signaling, which is an important process for the regulation of cellular processes that are essential for growth, development, and survival.

In conclusion, LRRC8C is a protein that has been shown to play a role in a number of important biological processes. Its potential as a drug target makes it an attractive target for researchers to investigate further, and its role in various biological processes suggests that it may be an important target for therapies aimed at improving human health. Further research is needed to fully understand the functions of LRRC8C and its potential as a drug target.

Protein Name: Leucine Rich Repeat Containing 8 VRAC Subunit C

Functions: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658, PubMed:28193731). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:33171122). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731)

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