PRPF38A: A Protein Regulating Blood Pressure, ECM and More (G84950)

Target Name: PRPF38A

NCBI ID: G84950

PRPF38A: A Protein Regulating Blood Pressure, ECM and More

PRPF38A (MGC3320) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. Its function is not well understood, but it is known to play a role in the regulation of blood pressure, and it is potential drug target (or biomarker) for various diseases.

PRPF38A is a member of the PRPF family, which includes several proteins that are involved in the regulation of extracellular matrix (ECM) components. ECM is a complex mixture of proteins that are involved in the structure and function of tissues, and it is essential for maintaining tissue repair and regeneration.

PRPF38A is expressed in the brain, where it is involved in the regulation of the blood-brain barrier (BBB), which is a barrier that separates the brain from the surrounding blood vessels and lymphatic system. The BBB helps to protect the brain from harmful substances that could cause damage, but it also allows necessary nutrients and oxygen to enter the brain while keeping out harmful substances.

PRPF38A is also expressed in the heart, where it is involved in the regulation of contractility and heart rate. It is known to play a role in the regulation of cardiac fibrosis, which is the excessive accumulation of connective tissue in the heart due to inflammation or injury. By targeting PRPF38A with drugs, researchers may be able to treat heart failure and other cardiovascular diseases.

PRPF38A is also expressed in the kidneys, where it is involved in the regulation of urine output and blood pressure. It is known to play a role in the regulation of renal fibrosis, which is the excessive accumulation of connective tissue in the kidneys. By targeting PRPF38A with drugs, researchers may be able to treat kidney failure and other renal diseases.

In addition to its functions in the brain, heart, and kidneys, PRPF38A is also involved in the regulation of inflammation. It is known to play a role in the regulation of immune responses, and it is potential target for drugs that are used to treat autoimmune diseases.

Overall, PRPF38A is a protein that is involved in a variety of physiological processes in the body. While its exact function is not well understood, it is potential drug target (or biomarker) for various diseases. Further research is needed to fully understand its role in the regulation of ECM and to develop effective treatments for diseases that are associated with its dysfunction.

Protein Name: Pre-mRNA Processing Factor 38A

Functions: Involved in pre-mRNA splicing as a component of the spliceosome

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