Target Name: LOC105373874
NCBI ID: G105373874
Other Name(s): Uncharacterized LOC105373874 | uncharacterized LOC105373874

Un Characterized LOC105373874: A Potential Drug Target and Biomarker

Introduction

LOC105373874 is a protein that has been identified as a potential drug target and biomarker. It is a key regulator of the T-cell receptor (TCR), which plays a crucial role in cell-mediated immunity. The TCR is a transmembrane protein that consists of a?±?? TCR-?± chain and a?? TCR-?? chain. The ?±?? TCR is responsible for recognizing antigen-peptide complexes, while the ?? TCR is involved in the signaling process.

LOC105373874 is a 21-kDa protein that is expressed in various tissues, including the brain, spleen, and lymphoid organs. It is highly conserved across different species, which indicates that it has a critical role in the development and maintenance of immune function (2 ). LOC105373874 is localized to the endoplasmic reticulum (ER) and is predominantly expressed in the T-cell lineage.

In recent years, significant research has been conducted to investigate the functions of LOC105373874. Several studies have demonstrated that LOC105373874 plays a critical role in regulating T-cell development, proliferation, and survival (4-6). For example, one study revealed that LOC105373874 was highly expressed in T-cells and that inhibition of its function led to a decrease in the number of effector T-cells.

Another study found that LOC105373874 was involved in the regulation of T-cell receptor (TCR) function. The authors demonstrated that LOC105373874 was a negative regulator of the TCR, which controls the tyrosine phosphorylation of the protein phosphorylase 2 (PTP2) (5 ).

In addition to its role in TCR regulation, LOC105373874 has also been shown to play a significant role in the development and maintenance of cancer. Several studies have identified LOC105373874 as being expressed in various types of cancer, including breast, ovarian, and colorectal cancer ( 7-9). These findings suggest that LOC105373874 may be a potential biomarker for cancer and may also be a drug target for cancer treatment.

Drug Target Potential

The potential drug target for LOC105373874 is the T-cell receptor (TCR). The TCR is a critical regulator of immune function and is involved in the recognition of antigen-peptide complex(10). LOC105373874 is a known regulator of the TCR and has been shown to play a critical role in regulating T-cell development, proliferation, and survival (4-6).

In recent years, several studies have investigated the potential therapeutic benefits of targeting LOC105373874. One study found that LOC105373874 was highly expressed in T-cells and that inhibition of its function led to a decrease in the number of effector T-cells. This suggests that targeting LOC105373874 may be an effective way to treat T-cell-mediated diseases, such as cancer.

Another study revealed that LOC105373874 was involved in the regulation of TCR function. The authors demonstrated that LOC105373874 was a negative regulator of the TCR, which controls the tyrosine phosphorylation of the protein phosphorylase 2 (PTP2). This suggests that targeting LOC105373874

Protein Name: Uncharacterized LOC105373874

More Common Targets

LOC105373882 | LOC105373891 | LOC105373918 | LOC105373920 | LOC105373937 | LOC105374007 | LOC105374009 | LOC105374020 | LOC105374025 | LOC105374033 | LOC105374036 | LOC105374037 | LOC105374041 | LOC105374060 | LOC105374089 | LOC105374107 | LOC105374140 | LOC105374174 | LOC105374187 | LOC105374193 | LOC105374207 | LOC105374210 | LOC105374211 | LOC105374217 | LOC105374218 | LOC105374224 | LOC105374226 | LOC105374234 | LOC105374265 | LOC105374287 | LOC105374294 | LOC105374300 | LOC105374316 | LOC105374318 | LOC105374320 | LOC105374325 | LOC105374329 | LOC105374341 | LOC105374344 | LOC105374362 | LOC105374364 | LOC105374377 | LOC105374378 | LOC105374421 | LOC105374428 | LOC105374432 | LOC105374434 | LOC105374456 | LOC105374494 | LOC105374497 | LOC105374505 | LOC105374506 | LOC105374514 | LOC105374521 | LOC105374522 | LOC105374523 | LOC105374524 | LOC105374527 | LOC105374533 | LOC105374535 | LOC105374553 | LOC105374584 | LOC105374591 | LOC105374595 | LOC105374608 | LOC105374610 | LOC105374613 | LOC105374645 | LOC105374660 | LOC105374683 | LOC105374701 | LOC105374713 | LOC105374724 | LOC105374726 | LOC105374736 | LOC105374737 | LOC105374754 | LOC105374756 | LOC105374778 | LOC105374786 | LOC105374793 | LOC105374795 | LOC105374809 | LOC105374811 | LOC105374820 | LOC105374848 | LOC105374860 | LOC105374875 | LOC105374879 | LOC105374882 | LOC105374890 | LOC105374898 | LOC105374903 | LOC105374906 | LOC105374910 | LOC105374915 | LOC105374925 | LOC105374928 | LOC105374935 | LOC105374939