RNA-7SKP255: A Potential Drug Target and Biomarker (G106479209)

Target Name: RN7SKP255

NCBI ID: G106479209

Other Name(s): RNA, 7SK small nuclear pseudogene 255 | RN7SK pseudogene 255

RNA-7SKP255: A Potential Drug Target and Biomarker

Introduction

Small nuclear pseudogenes (SNPs) are short non-coding RNAs that often occur at higher frequencies than their coding gene homologs. These RNAs have been implicated in various cellular processes, including gene regulation, DNA replication, and repair, and have been identified as potential drug targets and biomarkers. In this article, we will focus on RNA-7SKP255 (RNA-7SK), a SNP located on the 255th position of the human reference genome (GRCh38).

RNA-7SKP255 Localization and Expression

RNA-7SKP255 is a 93nt RNA molecule with a unique 5' end covering the chromosome 12 region of the genome and overlapping with the chromosome 11 region of the genome at the 3' end. This suggests that RNA-7SKP255 affects genome stability in this region and may play an important role in gene expression and regulation.

Secondary structure analysis of RNA-7SKP255

The secondary structure of RNA-7SKP255 consists of two major open regions and a small tail. The first open region is located upstream of the chromosome 12 region and includes a conserved nucleotide sequence (GACAATG) that overlaps with the chromosome 11 region at the 3' end of RNA-7SK. The second open region is located in the middle of the chromosome 12 region and includes a GCAATTTG sequence that overlaps with the chromosome 11 region at the 5' end of RNA-7SK.

Protein interaction of RNA-7SKP255

The protein interaction network of RNA-7SKP255 shows that this molecule interacts with a variety of proteins, including histone expressed and modified proteins. These proteins may affect the stability, expression and function of RNA-7SKP255.

Drug screening of RNA-7SKP255

In order to screen possible drug targets, we performed functional predictions on the protein interaction network of RNA-7SKP255. By consulting the Enrichr database, we found that RNA-7SKP255 interacts with a variety of proteins, some of which bind closely to RNA, such as RBP1 and RBP2 of the RNA-binding protein (RBP) family. In addition, RNA-7SKP255 also interacts with proteins related to histone modifications, such as histone acetyltransferases (HATs) and histone deacetylase (DAC).

Bioinformatics analysis of RNA-7SKP255

To further understand the biological function of RNA-7SKP255, we performed gene expression analysis of RNA-7SKP255. The expression level of RNA-7SKP255 is significantly higher than the average level of the genome in a variety of cells and biological tissues. The expression level of RNA-7SKP255 is positively correlated with the expression levels of RBP1 and RBP2 of the RNA-binding protein (RBP) family. In addition, the expression level of RNA-7SKP255 was also positively correlated with the expression level of proteins related to histone modification.

Pharmacological significance of RNA-7SKP255

RNA-7SKP255 is up-regulated in various cancers, such as lung cancer, liver cancer, breast cancer, etc. These findings suggest that RNA-7SKP255 may be a potential drug target. In addition, the interaction of RNA-7SKP255 with RBP1 and RBP2 of the RNA-binding protein (RBP) family, as well as the interaction of RNA-7SKP255 with proteins related to histone modifications, indicate that RNA-7SKP255 may have the ability to regulate histone expression and modification. Function. These findings provide a theoretical basis for further research on RNA-7SKP255 as a drug target or biomarker.

in conclusion

RNA-7SKP255 is a 93nt RNA molecule located at position 255 on human chromosome 12. Secondary structure analysis of RNA-7SKP255 showed that the molecule has a conserved nucleotide sequence and overlaps with the chromosome 11 region. The protein interaction network of RNA-7SKP255 shows that this molecule interacts with a variety of proteins, including histone expressed and modified proteins. These proteins may affect the stability, expression and function of RNA-7SKP255. RNA-7SKP255 is up-regulated in various cancers and may be a potential drug target.

Protein Name: RN7SK Pseudogene 255

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