CRKL Gene as Potential Drug Target for Cancer Treatment (G1399)

Target Name: CRKL

NCBI ID: G1399

CRKL Gene as Potential Drug Target for Cancer Treatment

CRKL (v-Crk sarcoma virus CT10 oncogene homolog (avian)-like) is a gene that has been identified as a potential drug target or biomarker for the treatment of various diseases, including cancer. The CRKL gene is located on chromosome 1p36 and encodes a protein known as CRKL.

CRKL is a viral oncogene homolog (AVI) that is known to be involved in the development and progression of various diseases, including cancer. The CRKL gene has been shown to be expressed in a variety of tissues and organs, including the brain, spinal cord, and testes, and has been linked to the development of neurodegenerative diseases, as well as cancer.

One of the key features of CRKL is its ability to induce cell transformations, such as the transformation of normal cells into cancer cells. This process is thought to be caused by the activation of various oncogenic signaling pathways, including the TGF-β pathway.

In addition to its ability to induce cell transformations, CRKL has also been shown to play a role in the regulation of cell proliferation and apoptosis. Specifically, the CRKL gene has been shown to encode a protein that is involved in the regulation of the p53 gene, which is a well-known tumor suppressor gene that plays a critical role in the regulation of cell apoptosis.

The CRKL gene has also been shown to be involved in the regulation of cell adhesion and migration. Specifically, the CRKL gene has been shown to encode a protein that is involved in the regulation of cell adhesion and the movement of cells along the body's extracellular matrix (ECM).

These findings suggest that CRKL may be a promising drug target or biomarker for the treatment of various diseases, including cancer. However, further research is needed to fully understand the role of CRKL in the development and progression of these diseases.

Protein Name: CRK Like Proto-oncogene, Adaptor Protein

Functions: May mediate the transduction of intracellular signals

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