Estrogen receptor (nonspecified subtype) Related Diseases

Estrogen receptor (nonspecified subtype)

Related Diseases

1) Arthritis
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

2) Crohn's Disease

3) Migraine
Migraine with or Without Aura 1, also known as migraine, is related to familial hemiplegic migraine and migraine without aura, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Migraine with or Without Aura 1 is NOTCH3 (Notch Receptor 3), and among its related pathways/superpathways are Type II diabetes mellitus and Cellular roles of Anthrax toxin. The drugs Mineral oil and Betamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and cortex, and related phenotypes are photophobia and vomiting

4) Metabolic Diseases
3-Hydroxyacyl-Coa Dehydrogenase Deficiency, also known as hadh deficiency, is related to long-chain 3-hydroxyacyl-coa dehydrogenase deficiency and hyperinsulinemic hypoglycemia, familial, 4, and has symptoms including emaciation An important gene associated with 3-Hydroxyacyl-Coa Dehydrogenase Deficiency is HADH (Hydroxyacyl-CoA Dehydrogenase). The drugs Naloxone and Buprenorphine have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and skeletal muscle, and related phenotypes are feeding difficulties in infancy and growth delay

5) Postpartum Depression
Postpartum Depression, also known as depression, postpartum, is related to major depressive disorder and mood disorder, and has symptoms including pelvic pain and mental and behavioral signs and symptoms. An important gene associated with Postpartum Depression is CRH (Corticotropin Releasing Hormone), and among its related pathways/superpathways are Signal Transduction and Myometrial relaxation and contraction pathways. The drugs Copper and Ethinylestradiol have been mentioned in the context of this disorder. Affiliated tissues include breast, brain and thyroid, and related phenotypes are nervous system and homeostasis/metabolism

6) Stroke, Ischemic
Stroke, Ischemic, also known as cerebral infarction, is related to sneddon syndrome and brain small vessel disease 1, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Stroke, Ischemic is F5 (Coagulation Factor V), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Diseases of hemostasis. The drugs Heparin, bovine and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include Bone and Brain, and related phenotypes are stroke and homeostasis/metabolism

7) Stroke
Cerebrovascular Disease, also known as cerebrovascular disorder, is related to basal ganglia cerebrovascular disease and stroke, ischemic, and has symptoms including headache, transient ischemic attacks, stereotypic symptoms and angina pectoris. An important gene associated with Cerebrovascular Disease is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Signal Transduction and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Acetylcarnitine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region

8) Infertility, Male
Male Infertility, also known as infertility, male, is related to spermatogenic failure 9 and infertility, and has symptoms including subfertility, male, inability to conceive due to male infertility and inability to impregnate. An important gene associated with Male Infertility is CFTR (CF Transmembrane Conductance Regulator), and among its related pathways/superpathways are Male infertility and Ovarian infertility. The drugs Progesterone and Dydrogesterone have been mentioned in the context of this disorder. Affiliated tissues include Testis, and related phenotypes are no effect and no effect

9) Infertility
Infertility is related to male infertility and female infertility due to zona pellucida defect, and has symptoms including pelvic pain An important gene associated with Infertility is DNAH5 (Dynein Axonemal Heavy Chain 5), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and G alpha (s) signalling events. The drugs Dinoprostone and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include ovary, uterus and pituitary, and related phenotypes are endocrine/exocrine gland and digestive/alimentary

10) Diabetes Type 2
Type 2 Diabetes Mellitus, also known as insulin resistance, is related to diabetes mellitus and maturity-onset diabetes of the young, type 8, with exocrine dysfunction, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Type 2 Diabetes Mellitus is IRS1 (Insulin Receptor Substrate 1), and among its related pathways/superpathways are Nervous system development and Angiopoietin-like protein 8 regulatory pathway. The drugs Glipizide and Glycopyrronium have been mentioned in the context of this disorder. Affiliated tissues include Pancreas and Adipose, and related phenotypes are type ii diabetes mellitus and insulin resistance

11) Diabetes Type 1
Type 1 Diabetes Mellitus, also known as diabetes mellitus, insulin-dependent, is related to type 1 diabetes mellitus 12 and type 1 diabetes mellitus 5, and has symptoms including polyuria and polydipsia. An important gene associated with Type 1 Diabetes Mellitus is HNF1A (HNF1 Homeobox A), and among its related pathways/superpathways are IL-9 Signaling Pathways and Immune response NFAT in immune response. The drugs Rituximab and Glipizide have been mentioned in the context of this disorder. Affiliated tissues include Bone and Pancreas, and related phenotypes are diabetes mellitus and polydipsia

12) Coronary Heart Disease
Coronary Heart Disease 1, also known as coronary heart disease, is related to angina pectoris and abdominal obesity-metabolic syndrome 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Coronary Heart Disease 1 is CX3CR1 (C-X3-C Motif Chemokine Receptor 1), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Simvastatin and Lovastatin have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are Increased free cholesterol and Increased LDL uptake

13) Coronary Artery Disease
Coronary Heart Disease 1, also known as coronary heart disease, is related to angina pectoris and abdominal obesity-metabolic syndrome 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Coronary Heart Disease 1 is CX3CR1 (C-X3-C Motif Chemokine Receptor 1), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Simvastatin and Lovastatin have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are Increased free cholesterol and Increased LDL uptake

14) Prostatitis
Prostatitis is related to prostate disease and paine syndrome, and has symptoms including prostatism An important gene associated with Prostatitis is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Saw palmetto and Cycloserine have been mentioned in the context of this disorder. Affiliated tissues include prostate, spinal cord and brain, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

15) Atherosclerosis
Atherosclerosis Susceptibility, also known as atherosclerosis, is related to cerebral atherosclerosis and generalized atherosclerosis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Atherosclerosis Susceptibility is ATHS (Atherosclerosis Susceptibility (Lipoprotein Associated)), and among its related pathways/superpathways are "Plasma lipoprotein assembly, remodeling, and clearance" and Interleukin-4 and Interleukin-13 signaling. The drugs Enalaprilat and Enalapril have been mentioned in the context of this disorder. Affiliated tissues include Heart, and related phenotypes are hypertriglyceridemia and myocardial infarction

16) Asthma
Asthma, also known as chronic obstructive asthma, is related to allergic asthma and childhood-onset asthma, and has symptoms including recurring periods of wheezing, chest tightness and shortness of breath. An important gene associated with Asthma is IL13 (Interleukin 13), and among its related pathways/superpathways are Allograft rejection and Interleukin-4 and Interleukin-13 signaling. The drugs Fentanyl and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include Lung, smooth muscle and skin, and related phenotypes are asthma and bronchoconstriction

17) Multiple Sclerosis
Multiple Sclerosis, also known as ms, is related to pediatric multiple sclerosis and autoimmune hepatitis, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Phosphorylation of CD3 and TCR zeta chains and Cell differentiation - expanded index. The drugs Acetaminophen and Promethazine have been mentioned in the context of this disorder. Affiliated tissues include Neural Tube and Limb, and related phenotypes are spasticity and diplopia

18) Endometrial Hyperplasia
Endometrial Hyperplasia is related to endometrial adenocarcinoma and adenomyosis. An important gene associated with Endometrial Hyperplasia is PGR (Progesterone Receptor), and among its related pathways/superpathways are Gene expression (Transcription) and Signal Transduction. The drugs BIRC5 protein, human and Estrogens, Conjugated (USP) have been mentioned in the context of this disorder. Affiliated tissues include uterus, pituitary and ovary, and related phenotypes are no effect and no effect

19) Endometriosis
Endometriosis, also known as endometriosis, site unspecified, is related to endometriosis of ovary and endometrial adenocarcinoma, and has symptoms including pelvic pain and pain and other symptoms associated with female genital organs. An important gene associated with Endometriosis is ENDO1 (Endometriosis, Susceptibility To, 1), and among its related pathways/superpathways are miRNAs involvement in the immune response in sepsis and Cell differentiation - expanded index. The drugs Dienogest and Progesterone have been mentioned in the context of this disorder. Affiliated tissues include uterus, ovary and skin.

20) Cervicitis
Cervicitis, also known as uterine cervicitis, is related to acute gonococcal cervicitis and acute cervicitis. An important gene associated with Cervicitis is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Azithromycin and Tetracycline have been mentioned in the context of this disorder. Affiliated tissues include cervix, uterus and breast, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

21) Acne Vulgaris
Acne, also known as acne vulgaris, is related to sapho syndrome and hidradenitis suppurativa, and has symptoms including exanthema and pruritus. An important gene associated with Acne is NCSTN (Nicastrin), and among its related pathways/superpathways are Innate Immune System and Prolactin Signaling. The drugs Calcipotriol and Adapalene have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and thyroid, and related phenotypes are no effect and no effect

22) Parkinson's Disease
Parkinson Disease, Late-Onset, also known as parkinson disease, is related to hereditary late-onset parkinson disease and parkinson disease 3, autosomal dominant, and has symptoms including angina pectoris, back pain and headache. An important gene associated with Parkinson Disease, Late-Onset is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways is Parkinson's disease pathway. The drugs Idebenone and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include Brain, and related phenotypes are hallucinations and abnormal autonomic nervous system physiology

23) Heart Failure
Congestive Heart Failure, also known as congestive heart disease, is related to cardiomyopathy, dilated, 1e and orthostatic intolerance, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Congestive Heart Failure is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Cardiac conduction and "Antiarrhythmic Pathway, Pharmacodynamics". The drugs Salbutamol and Thalidomide have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Lateral Plate Mesoderm, and related phenotypes are muscle and homeostasis/metabolism

24) Hypogonadism
Hypogonadism is related to hypogonadotropic hypogonadism 1 with or without anosmia and hypogonadotropic hypogonadism 7 with or without anosmia. An important gene associated with Hypogonadism is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are GPCR downstream signalling and Signal Transduction. The drugs Liraglutide and Dihydrotachysterol have been mentioned in the context of this disorder. Affiliated tissues include testes, pituitary and prostate, and related phenotypes are no effect and no effect

25) Mood Disorder
Mood Disorder, also known as mood disorders, is related to major depressive disorder and schizoaffective disorder, and has symptoms including alexithymia and psychiatric symptom. An important gene associated with Mood Disorder is DISC2 (Disrupted In Schizophrenia 2), and among its related pathways/superpathways are Signal Transduction and GPCR downstream signalling. The drugs Lithium carbonate and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and pituitary, and related phenotypes are nervous system and homeostasis/metabolism

26) Duchenne Muscular Dystrophy
Muscular Dystrophy, Duchenne Type, also known as duchenne muscular dystrophy, is related to muscular dystrophy, becker type and facioscapulohumeral muscular dystrophy 1, and has symptoms including waddling gait and weakness. An important gene associated with Muscular Dystrophy, Duchenne Type is DMD (Dystrophin), and among its related pathways/superpathways are Cell differentiation - expanded index and miRNAs involvement in the immune response in sepsis. The drugs Carvedilol and Ramipril have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Umbilical Cord, and related phenotypes are scoliosis and respiratory insufficiency

27) Depression
Major Depressive Disorder, also known as seasonal affective disorder, is related to anxiety and endogenous depression, and has symptoms including affective symptoms, behavioral symptoms and schizophrenic language. An important gene associated with Major Depressive Disorder is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are Signal Transduction and Neuroscience. The drugs Fluvoxamine and Valsartan have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are depression and behavior/neurological

28) Inflammatory Bowel Disease
Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to inflammatory bowel disease 6 and inflammatory bowel disease 9. An important gene associated with Inflammatory Bowel Disease is IL37 (Interleukin 37). The drugs Copper and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and bone marrow.

29) Anxiety Disorders
Anxiety, also known as anxiety disorders, is related to generalized anxiety disorder and separation anxiety disorder, and has symptoms including nervousness, agitation and feeling tense. An important gene associated with Anxiety is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Signal Transduction and Class A/1 (Rhodopsin-like receptors). The drugs Amlodipine and Lorazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and thyroid, and related phenotypes are nervous system and normal

30) Gynecomastia
Gynecomastia is related to 17-beta hydroxysteroid dehydrogenase iii deficiency and androgen insensitivity, partial. An important gene associated with Gynecomastia is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1), and among its related pathways/superpathways are Metabolism of proteins and Signal Transduction. The drugs (R)-Bicalutamide and Tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and testis, and related phenotypes are homeostasis/metabolism and nervous system

31) Keloid
Keloid Disorder, also known as keloid, is related to scleroderma, familial progressive and peyronie's disease. An important gene associated with Keloid Disorder is H19 (H19 Imprinted Maternally Expressed Transcript), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and DNA damage response (only ATM dependent). The drugs Bleomycin and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and bone marrow, and related phenotypes are digestive/alimentary and skeleton

32) Cancer, Breast
Breast Cancer, also known as breast carcinoma, is related to ovarian cancer and hereditary breast ovarian cancer syndrome, and has symptoms including pelvic pain, lameness, animal and pain. An important gene associated with Breast Cancer is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Gene expression (Transcription) and ERK Signaling. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related phenotypes are breast carcinoma and Decreased viability

33) Cancer, Prostate
Prostate Cancer, also known as prostate carcinoma, is related to breast cancer and prostate disease, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Prostate Cancer is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are Endometrial cancer and Breast cancer pathway. The drugs Sodium citrate and Sildenafil have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and lymph node, and related phenotypes are prostate cancer and neoplasm

34) Cancer, Bladder
Bladder Cancer, also known as urinary bladder cancer, is related to bladder urothelial carcinoma and costello syndrome. An important gene associated with Bladder Cancer is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways are Breast cancer pathway and MAPK Signaling: Mitogens. The drugs Tamsulosin and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include urinary bladder, lymph node and prostate, and related phenotypes are transitional cell carcinoma of the bladder and bladder neoplasm

35) Anorexia Nervosa
Anorexia Nervosa, also known as anorexia nervosa, susceptibility to, is related to eating disorder and body dysmorphic disorder, and has symptoms including decrease in appetite An important gene associated with Anorexia Nervosa is HTR2A (5-Hydroxytryptamine Receptor 2A), and among its related pathways/superpathways are GPCR downstream signalling and Signal Transduction. The drugs Aripiprazole and Fluoxetine have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and prefrontal cortex, and related phenotypes are Reduced mammosphere formation and nervous system

36) Glioma
Glial Tumor, also known as glioma, is related to optic nerve glioma and brain stem glioma. The drugs Trametinib and Dabrafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and bone marrow.

37) Rheumatoid Arthritis
Rheumatoid Arthritis, also known as ra, is related to arthritis and psoriatic arthritis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rheumatoid Arthritis is PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22), and among its related pathways/superpathways are NF-kappaB Signaling and Genes associated with the development of rheumatoid arthritis. The drugs Entecavir and Alendronic acid have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, joint and bone, and related phenotypes are joint stiffness and fatigue

38) Acne
Acne, also known as acne vulgaris, is related to sapho syndrome and hidradenitis suppurativa, and has symptoms including exanthema and pruritus. An important gene associated with Acne is NCSTN (Nicastrin), and among its related pathways/superpathways are Innate Immune System and Prolactin Signaling. The drugs Calcipotriol and Adapalene have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and thyroid, and related phenotypes are no effect and no effect

39) Diabetes
Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11), and among its related pathways/superpathways are Regulation of beta-cell development and Cell differentiation - expanded index. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and kidney.

40) Lupus Erythematosus
Lupus Erythematosus, also known as lupus, is related to systemic lupus erythematosus and systemic lupus erythematosus 16, and has symptoms including rashes, exanthema and pruritus. An important gene associated with Lupus Erythematosus is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and t cells, and related phenotypes are no effect and no effect

41) Premenstrual Syndrome
Premenstrual Tension, also known as premenstrual syndrome, is related to neurotic disorder and endogenous depression, and has symptoms including pelvic pain, unspecified symptom associated with female genital organs and mittelschmerz. An important gene associated with Premenstrual Tension is GNRH1 (Gonadotropin Releasing Hormone 1), and among its related pathways/superpathways are Prader-Willi and Angelman syndrome and "Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics". The drugs Estradiol and Polyestradiol phosphate have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and liver.

42) Ischemia
Ischemia, also known as acute coronary syndrome, is related to limb ischemia and lipoprotein quantitative trait locus, and has symptoms including anoxemia, polydipsia and muscle weakness. An important gene associated with Ischemia is LINC01254 (Long Intergenic Non-Protein Coding RNA 1254), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Lovastatin and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and brain, and related phenotypes are homeostasis/metabolism and nervous system

43) Liver Diseases
Liver Disease, also known as liver diseases, is related to non-alcoholic fatty liver disease and fatty liver disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Disease is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Perindopril and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and kidney, and related phenotypes are Reduced mammosphere formation and liver/biliary system

44) Hepatic Steatosis
Fatty Liver Disease, Nonalcoholic 1, also known as nafld1, is related to non-alcoholic fatty liver disease and fatty liver disease. An important gene associated with Fatty Liver Disease, Nonalcoholic 1 is ATG7 (Autophagy Related 7). The drugs Metformin and Entecavir have been mentioned in the context of this disorder. Affiliated tissues include liver, skeletal muscle and kidney, and related phenotype is hepatic steatosis.

45) Acromegaly
Acromegaly, also known as gigantism, is related to pituitary adenoma 1, multiple types and pituitary tumors, and has symptoms including endocrine system signs and symptoms An important gene associated with Acromegaly is AIP (Aryl Hydrocarbon Receptor Interacting Protein), and among its related pathways/superpathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors). The drugs Somatostatin and Liraglutide have been mentioned in the context of this disorder. Affiliated tissues include limb, pituitary and bone, and related phenotypes are hyperhidrosis and macroglossia

46) Obesity
Body Mass Index Quantitative Trait Locus 11, also known as obesity, is related to leptin deficiency or dysfunction and type 2 diabetes mellitus, and has symptoms including high weight, symptoms and obesity, metabolically benign. An important gene associated with Body Mass Index Quantitative Trait Locus 11 is UCP3 (Uncoupling Protein 3), and among its related pathways/superpathways are Beta-2 adrenergic-dependent CFTR expression and Glucose / Energy Metabolism. The drugs Hydrocortisone and Hydrocortisone succinate have been mentioned in the context of this disorder. Affiliated tissues include skeletal muscle, liver and heart, and related phenotypes are obesity and decreased resting energy expenditure

47) Insulin Resistance
Type 2 Diabetes Mellitus, also known as insulin resistance, is related to diabetes mellitus and maturity-onset diabetes of the young, type 8, with exocrine dysfunction, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Type 2 Diabetes Mellitus is IRS1 (Insulin Receptor Substrate 1), and among its related pathways/superpathways are Nervous system development and Angiopoietin-like protein 8 regulatory pathway. The drugs Glipizide and Glycopyrronium have been mentioned in the context of this disorder. Affiliated tissues include Pancreas and Adipose, and related phenotypes are type ii diabetes mellitus and insulin resistance

48) Glioblastoma
Glioblastoma, also known as glioblastoma multiforme, is related to brain cancer and glioma, and has symptoms including headache and seizures. An important gene associated with Glioblastoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways is miRNAs involved in DNA damage response. The drugs Trametinib and Dabrafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and eye, and related phenotypes are glioblastoma multiforme and abnormal cell morphology

49) Seborrheic Dermatitis
Seborrheic Infantile Dermatitis, also known as cradle cap, is related to seborrheic dermatitis and dermatitis. An important gene associated with Seborrheic Infantile Dermatitis is DOP1B (DOP1 Leucine Zipper Like Protein B). The drugs Ciclopirox and Ketoconazole have been mentioned in the context of this disorder. Affiliated tissues include skin and liver.

50) Cerebrovascular Disorders
Cerebrovascular Disease, also known as cerebrovascular disorder, is related to basal ganglia cerebrovascular disease and stroke, ischemic, and has symptoms including headache, transient ischemic attacks, stereotypic symptoms and angina pectoris. An important gene associated with Cerebrovascular Disease is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Signal Transduction and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Acetylcarnitine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region

51) Alopecia
Alopecia is related to alopecia universalis congenita and alopecia-mental retardation syndrome 1, and has symptoms including exanthema and pruritus. An important gene associated with Alopecia is SASH1 (SAM And SH3 Domain Containing 1), and among its related pathways/superpathways are Direct p53 effectors and Validated transcriptional targets of TAp63 isoforms. The drugs Cetirizine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include Hair, and related phenotypes are no effect and no effect

52) Autoimmune Disease
Autoimmune Disease, also known as autoimmune diseases, is related to vitiligo-associated multiple autoimmune disease susceptibility 1 and systemic lupus erythematosus. An important gene associated with Autoimmune Disease is AIS4 (Autoimmune Disease, Susceptibility To, 4), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Sofosbuvir and Ledipasvir have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and skin, and related phenotypes are autoimmune antibody positivity and endocrine/exocrine gland

53) Dyslipidemia
Lipid Metabolism Disorder, also known as dyslipidemia, is related to hyperlipoproteinemia, type iii and hypobetalipoproteinemia, familial, 1. An important gene associated with Lipid Metabolism Disorder is LIPC (Lipase C, Hepatic Type), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Tocopherol and Aripiprazole have been mentioned in the context of this disorder. Affiliated tissues include liver, heart and bone marrow, and related phenotypes are no effect and no effect

54) Hereditary Hemorrhagic Telangiectasia
Telangiectasia, Hereditary Hemorrhagic, Type 1, also known as orw disease, is related to juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome and pulmonary hypertension, primary, 1, and has symptoms including cyanosis, dyspnea and seizures. An important gene associated with Telangiectasia, Hereditary Hemorrhagic, Type 1 is ENG (Endoglin), and among its related pathways/superpathways are TGF-beta Signaling Pathways and ALK1 signaling events. The drugs Bevacizumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include lung, liver and brain, and related phenotypes are telangiectasia of the skin and hemoptysis

55) Androgenic Alopecia
Androgenic Alopecia, also known as androgenetic alopecia, is related to alopecia, androgenetic, 1 and alopecia. An important gene associated with Androgenic Alopecia is SRD5A2 (Steroid 5 Alpha-Reductase 2), and among its related pathways/superpathways are Signal Transduction and Nanog in Mammalian ESC Pluripotency. The drugs Cetirizine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include skin, prostate and ovary, and related phenotypes are no effect and no effect

56) Tremor
Tremor, also known as medication-induced postural tremor, is related to tremor, hereditary essential, 1 and fragile x-associated tremor/ataxia syndrome. An important gene associated with Tremor is STXBP1 (Syntaxin Binding Protein 1), and among its related pathways/superpathways are Neuroscience and Parkinson's disease pathway. The drugs Propranolol and Memantine have been mentioned in the context of this disorder. Affiliated tissues include brain, thyroid and subthalamic nucleus, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

57) Glaucoma
Intraocular Pressure Quantitative Trait Locus, also known as glaucoma, is related to primary angle-closure glaucoma and open-angle glaucoma. An important gene associated with Intraocular Pressure Quantitative Trait Locus is ZEB1 (Zinc Finger E-Box Binding Homeobox 1), and among its related pathways/superpathways are Clear cell renal cell carcinoma pathways and BMP signaling in eyelid development. The drugs Topiramate and Bromfenac have been mentioned in the context of this disorder. Affiliated tissues include Eye, retina and bone marrow, and related phenotypes are homeostasis/metabolism and nervous system

58) Osteoarthritis
Osteoarthritis, also known as osteoarthrosis, is related to cartilage disease and exostosis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Osteoarthritis is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are ECM proteoglycans and Extracellular matrix organization. The drugs Fentanyl and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Bone, and related phenotype is limbs/digits/tail.

59) Osteopetrosis
Osteopetrosis, also known as marble bone disease, is related to osteopetrosis, autosomal recessive 7 and osteopetrosis, autosomal recessive 5. An important gene associated with Osteopetrosis is CLCN7 (Chloride Voltage-Gated Channel 7), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Cyclophosphamide and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spleen, and related phenotypes are no effect and no effect

60) Osteoporosis
Bone Mineral Density Quantitative Trait Locus 8, also known as osteoporosis, is related to osteoporosis and bone mineral density quantitative trait locus 15, and has symptoms including angina pectoris, back pain and muscle cramp. An important gene associated with Bone Mineral Density Quantitative Trait Locus 8 is BMND8 (Bone Mineral Density Quantiative Trait Locus 8). The drugs Clobetasol and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord.

61) Osteoporosis, Postmenopausal
Osteoporosis, also known as postmenopausal osteoporosis, is related to osteoporosis, juvenile and bone mineral density quantitative trait locus 15, and has symptoms including angina pectoris, back pain and muscle cramp. An important gene associated with Osteoporosis is COL1A1 (Collagen Type I Alpha 1 Chain), and among its related pathways/superpathways are Breast cancer pathway and Vitamin D receptor pathway. The drugs Clobetasol and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include Bone, and related phenotypes are osteoporosis and homeostasis/metabolism

62) Hypertriglyceridemia
Hypertriglyceridemia, Transient Infantile, is also known as transient infantile hypertriglyceridemia and hepatosteatosis, and has symptoms including hypertriglyceridemic waist An important gene associated with Hypertriglyceridemia, Transient Infantile is GPD1 (Glycerol-3-Phosphate Dehydrogenase 1). The drugs Ciprofibrate and Glucagon have been mentioned in the context of this disorder. Affiliated tissues include liver, skeletal muscle and heart, and related phenotypes are splenomegaly and hepatomegaly

63) Hypercholesterolemia
Hypercholesterolemia, Familial, 3, also known as hypercholesterolemia, autosomal dominant, 3, is related to hyperaldosteronism, familial, type iii and strabismus. An important gene associated with Hypercholesterolemia, Familial, 3 is PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9). The drugs Probucol and Cilostazol have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and skin, and related phenotypes are hypercholesterolemia and xanthelasma

64) Hyperlipidemia
Familial Hyperlipidemia, also known as familial hyperlipoproteinemia, is related to hyperlipoproteinemia, type v and hyperlipoproteinemia, type i. An important gene associated with Familial Hyperlipidemia is APOB (Apolipoprotein B), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Evolocumab and Dapagliflozin have been mentioned in the context of this disorder. Affiliated tissues include heart, liver and endothelial, and related phenotypes are no effect and no effect

65) Hypertension
Hypertension, Essential, also known as essential hypertension, is related to pulmonary hypertension and renovascular hypertension, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Hypertension, Essential is PTGIS (Prostaglandin I2 Synthase), and among its related pathways/superpathways are Development Angiotensin activation of ERK and "Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics". The drugs Digoxin and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and eye, and related phenotypes are elevated systolic blood pressure and elevated diastolic blood pressure

66) McCune-Albright Syndrome
Mccune-Albright Syndrome, also known as polyostotic fibrous dysplasia, is related to fibrous dysplasia and acth-independent cushing syndrome. An important gene associated with Mccune-Albright Syndrome is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are Metabolism of proteins and ERK Signaling. The drugs Etidronic acid and Risedronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and thyroid, and related phenotypes are fibrous dysplasia of the bones and precocious puberty

67) Melanoma
Melanoma, also known as malignant melanoma, is related to skin melanoma and melanoma, cutaneous malignant 1, and has symptoms including exanthema and pruritus. An important gene associated with Melanoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Vindesine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and t cells, and related phenotypes are normal and pigmentation

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