Graves Disease
About the Disease
Graves' Disease, also known as graves disease, is related to graves disease 1 and exophthalmos. An important gene associated with Graves' Disease is GRD2 (Graves Disease, Susceptibility To, 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and NF-kappaB Signaling. The drugs Methimazole and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include thyroid gland, thyroid and eye, and related phenotypes are endocrine/exocrine gland and immune system
Common Targets / Biomarkers
IKZF1 | IL6 | VDR | GPR174 | ROCK1 | FOXO1 | HMGCR | TLR10 | CCR6 | CD247 | GHRL | MTNR1A | HLA-A | ITPR3 | MIF-AS1 | TNF | LCK | IFNGR1 | BCL2L1 | ICAM1 | IL1B | MUC22 | IL10 | CDC42BPG | FSHR | HCP5 | DPP4 | CEP128 | IL17A | PDE10A | PHTF1 | MIR3681HG | MTRR | RAC2 | CD40 | GHRLOS | KALRN | CD44 | LPP | TG | IL3 | IL1RL1 | TNFSF13B | TBX21 | AP4B1 | CTLA4 | MIR7-3HG | MAP3K11 | MCL1 | VCAM1 | FOXD3 | SMOC2 | MTNR1B | IL15 | DNMT3B | RARB | ARID5B | JAK2 | MS4A1 | LOC105377877 | COQ8A | IL2 | ZAP70 | FCRL3 | DDAH1 | BACH2 | CYP2R1 | FASLG | JAK1 | MIR182 | ROCK2 | JAK3 | CYP4F22 | IL5 | SLAMF6 | HLX | PTPN22 | TLR4 | IL4 | MIR27A | MAGI3 | NRXN1 | SLC25A24 | IKZF3 | MIR7-3 | FCRL2 | HLA-DQB1 | DNMT1 | IL18RAP | CD3E | MIF | TSHR | PRICKLE1 | HLA-DPB1 | FTO | HLA-C | CD5L | IFIH1 | CYP26B1 | IL13 | CXCL10 | ABCF1 | MIR125A | TLR7 | IRAK1 | HLA-DRB1 | C1QTNF6 | SH2B3 | SCGB3A2 | BCL2L15 | ABO | DCBLD1 | NFKB1 | ATF6 | IL18R1 | LOC101929772 | SLA2 | RND3 | BTG2-DT | RHOA | TSBP1 | FBXL18 | RHOC | FOXP3 | CD3D | HLA-B | ATXN2 | CD8A | IL12B | PPARG | LOC105376809 | LOC107985690 | MTHFR | RHOD | ZPBP2 | SELE | CD3 Complex (T Cell Receptor Complex) | PITPNC1 | LOC105372666 | TYK2 | VAV3 | BANK1 | MAGI2 | NR2F6 | PARP1 | MVB12B | NRXN3 | IL33 | HLA-DQA1 | ESR2 | HCG23 | SOCS3-DT | CD3G | IL2RA | NOTCH1 | CCN1 | THRB | KLF13
Other Diseases
Gray Platelet Syndrome | Greenberg Dysplasia | Greig Cephalopolysyndactyly Syndrome | Growth Hormone Excess | Guanidinoacetate Methyltransferase Deficiency | Guillain-Barre Syndrome | Guttate Psoriasis | Gynecomastia | Gyrate Atrophy Of The Choroid And Retina | H Syndrome | Haim-Munk Syndrome | Hairy Cell Leukemia | Hamartoma | HANAC Syndrome | Hartnup Disease | Hartsfield Syndrome | Hashimoto Thyroiditis | Headache | Heart Block | Heart Failure | Heart Septal Defects | Heavy Chain Disease | Heimler Syndrome | HELLP Syndrome | Hemangioblastoma | Hemangioendothelioma | Hemangioma | Hemimegalencephaly | Hemochromatosis | Hemochromatosis Type 1 | Hemochromatosis Type 2 | Hemoglobinopathies | Hemolytic Anemia | Hemolytic Uremic Syndrome | Hemolytic Uremic Syndrome, Atypical | Hemophagocytic Lymphohistiocytosis | Hemophilia | Hemorrhage | Hemorrhagic Disorders | Hemorrhoids | Hemosiderosis | Hennekam Lymphangiectasia-lymphedema Syndrome | Hepatic Adenomatosis | Hepatic Steatosis | Hepatic Veno-occlusive Disease | Hepatitis | Hepatitis A | Hepatitis B, Chronic | Hepatitis C, Chronic | Hepatitis D | Hepatitis E | Hepatitis, Alcoholic | Hepatitis, Autoimmune | Hepatitis, Chronic | Hepatoblastoma | Hepatopulmonary Syndrome | Hepatorenal Syndrome | Hereditary Coproporphyria | Hereditary Elliptocytosis | Hereditary Folate Malabsorption | Hereditary Hemorrhagic Telangiectasia | Hereditary Hemorrhagic Telangiectasia Type 2 | Hereditary Mixed Polyposis Syndrome | Hereditary Multiple Exostoses | Hereditary Neuropathy With Liability To Pressure Palsies | Hereditary Pyropoikilocytosis | Hereditary Sensory And Autonomic Neuropathy | Hereditary Sensory Neuropathy Type 1 | Hereditary Spastic Paraplegia | Hereditary Spherocytosis | Hereditary Xerocytosis | Hermansky-Pudlak Syndrome | Hernia, Inguinal | Herpes Genitalis | Herpes Simplex Dermatitis | Heterotopic Ossification | HIBCH Deficiency | Hidradenitis | Hidradenitis Suppurativa | High Molecular Weight Kininogen Deficiency | Histiocytic Sarcoma | Histiocytosis | Hodgkin Lymphoma | Holoprosencephaly | Holt-Oram Syndrome | Homocystinuria | Hoyeraal-Hreidarsson Syndrome | Huntington's Disease | Huntington's Disease-like 2 | HUPRA Syndrome | Hydrocephalus | Hydrocephalus, Normal Pressure | Hydrolethalus Syndrome | Hydronephrosis | Hydrops Fetalis | Hyper IgE Syndrome | Hyperacusis | Hyperammonemia | Hyperandrogenemia | Hyperbilirubinemia, Neonatal | Hypercalcemia | Hypercalciuria | Hypercholesterolemia | Hypercholesterolemia, Familial | Hyperekplexia | Hypereosinophilic Syndrome | Hyperferritinemia-cataract Syndrome | Hyperglycemia | Hyperhomocysteinemia | Hyperinsulinemia | Hyperinsulinemic Hypoglycemia | Hyperinsulinism-hyperammonemia Syndrome | Hyperkeratosis | Hyperlipidemia | Hyperlipidemia Type V | Hyperlipidemia, Familial Combined | Hypermethioninemia | Hypermetropia | Hyperostosis | Hyperoxaluria | Hyperparathyroidism | Hyperparathyroidism, Primary | Hyperparathyroidism, Secondary | Hyperparathyroidism-jaw Tumor Syndrome | Hyperphenylalaninemia | Hyperphosphatasia With Intellectual Disability Syndrome 4 | Hyperprolactinemia | Hypersensitivity | Hypersensitivity Pneumonitis | Hypersomnia | Hypertelorism | Hypertension | Hypertension, Essential | Hypertension, Portal | Hypertension, Pulmonary | Hypertension, Renal | Hypertension, Renovascular | Hypertensive Nephropathy | Hypertensive Retinopathy | Hyperthermia, Malignant | Hyperthyroidism | Hypertriglyceridemia | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1 | Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 2 | Hypertrophy | Hyperuricemia | Hyperuricemic Nephropathy, Familial Juvenile | Hypervalinemia | Hypoalbuminemia | Hypobetalipoproteinemias | Hypocalcemia | Hypodontia | Hypoglycemia | Hypogonadism | Hypohidrotic Ectodermal Dysplasia | Hypohidrotic Ectodermal Dysplasia, X-linked | Hypokalemia | Hypokalemic Periodic Paralysis | Hypolipoproteinemia | Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum | Hypoparathyroidism | Hypophosphatemic Rickets, Autosomal Recessive, 1 | Hypopigmentation | Hypopituitarism | Hypoplastic Left Heart Syndrome | Hypoproteinemia, Hypercatabolic | Hypospadias | Hypotension, Orthostatic | Hypothyroidism | Hypotonia-cystinuria Syndrome | Hypotrichosis | Hypotrichosis Simplex | Hypotrichosis, Congenital, With Juvenile Macular Dystrophy | ICF Syndrome | Ichthyosis | Ichthyosis Bullosa Of Siemens | Ichthyosis Hystrix, Curth-Macklin Type | Ichthyosis, X-linked | Idiopathic Multicentric Castleman Disease | Idiopathic Pulmonary Fibrosis | IgA Deficiency | IgA Nephropathy | Ileitis | IMAGe Syndrome | Imerslund-Grasbeck Syndrome | Immunoproliferative Disorders | Impetigo | Impulse Control Disorder | Inborn Errors Of Metabolism | Incontinentia Pigmenti | Infantile Liver Failure Syndrome 1 | Infantile Nephropathic Cystinosis | Infantile Neuroaxonal Dystrophy | Infantile Refsum Disease | Infantile Spasm | Infectious Diarrhea | Infertility | Infertility, Male | Inflammatory Bowel Disease | Inflammatory Joint Disease | Inflammatory Linear Verrucous Epidermal Nevus | Inflammatory Myofibroblastic Tumor | Inflammatory Myopathy | Influenza | Insulin Resistance | Insulinoma | Intellectual Disability, Autosomal Dominant 5 | Intermittent Claudication | Intermittent Explosive Disorder | Interstitial Lung Diseases | Intestinal Hypomagnesemia 1 | Intestinal Obstruction | Intestinal Pseudo-obstruction | Intestinal Tuberculosis | Intracerebral Hemorrhage | Intracranial Hypertension | Iron Deficiency Anemia | Iron Metabolism Disorders | Iron Overload | Irritable Bowel Syndrome | Ischemia | Isobutyryl-CoA Dehydrogenase Deficiency | Isovaleric Acidemia | Jacobsen Syndrome | Jalili Syndrome | Japanese Encephalitis | Jaundice, Obstructive | Jawad Syndrome | Johanson-Blizzard Syndrome | Joubert Syndrome | Joubert Syndrome 2 | Juvenile Hyaline Fibromatosis | Juvenile Myelomonocytic Leukemia | Juvenile Myoclonic Epilepsy | Juvenile Polyposis | Juvenile Xanthogranuloma | Kabuki Syndrome | Kabuki Syndrome 2 | Kallmann Syndrome | Kaposi Sarcoma | Kaposiform Hemangioendothelioma | Kashin-Beck Disease | Kawasaki Disease | KBG Syndrome | Kearns-Sayre Syndrome | Keloid | Keratitis | Keratitis-ichthyosis-deafness Syndrome | Keratoacanthoma | Keratoconjunctivitis | Keratoconus | Keratocystic Odontogenic Tumor | Keratopathy | Keratosis | Keratosis, Actinic | Keratosis, Seborrheic | Kernicterus | Kidney Stones | Kindler Syndrome | Kleine-Levin Syndrome | Klinefelter Syndrome | Klippel-Feil Syndrome | Knobloch Syndrome | Kohlschutter-Tonz Syndrome | Krabbe Disease | L-2-Hydroxyglutaric Aciduria | Lactose Intolerance | Lafora Disease | Lamellar Ichthyosis | Language Disorders | Large Granular Lymphocytic Leukemia | Larsen Syndrome | Lassa Fever | Lateral Meningocele Syndrome | Lathosterolosis | Lattice Corneal Dystrophy | Lattice Corneal Dystrophy Type 1 | Learning Disability | Leber Congenital Amaurosis | Leber Hereditary Optic Neuropathy | Left Ventricular Noncompaction | Leiomyoma | Leiomyosarcoma | Leishmaniasis, Cutaneous | Leishmaniasis, Visceral | Lennox-Gastaut Syndrome | Lentigo | LEOPARD Syndrome | Leprosy | Leri Pleonosteosis | Leri-Weill Dyschondrosteosis | Lesch-Nyhan Syndrome | Leukemia | Leukemia-lymphoma, Adult T-cell | Leukocyte Adhesion Deficiency | Leukocyte Adhesion Deficiency Type 1 | Leukodystrophies | Leukoencephalopathy, Progressive Multifocal | Leukoplakia | Leukoplakia, Oral | Lewy Body Dementia | Li-Fraumeni Syndrome | Lichen Planus | Lichen Sclerosus | Liddle Syndrome | Liebenberg Syndrome | Light Chain Amyloidosis | Ligneous Conjunctivitis | Limb Girdle Muscular Dystrophy | Lipid Metabolism Disorders | Lipid Storage Diseases | Lipid Storage Myopathy | Lipodystrophy | Lipoma | Lissencephaly 2 | Liver Diseases | Liver Failure | Liver Failure, Acute Infantile | LMNA-related Congenital Muscular Dystrophy | Localized Scleroderma | Loeys-Dietz Syndrome | Loeys-Dietz Syndrome Type 4 | Long QT Syndrome Type 1 | Long QT Syndrome Type 2 | Long QT Syndrome Type 3 | Long-chain 3-hydroxyacyl-coenzyme A Dehydrogenase Deficiency | Low Phospholipid Associated Cholelithiasis | Low Tension Glaucoma | LRBA Deficiency | Lung Diseases | Lupus Erythematosus | Lyme Disease | Lymphangioleiomyomatosis | Lymphangioma | Lymphangiomatosis | Lymphedema | Lymphedema-distichiasis Syndrome | Lymphoma | Lymphoma Lymphoblastic | Lymphoma, AIDS-related | Lymphoma, B-cell | Lymphoma, Follicular | Lymphoma, Mantle Cell | Lymphoma, Primary Cutaneous Anaplastic Large Cell | Lymphomatoid Granulomatosis | Lymphoproliferative Disease, X-linked | Lymphoproliferative Disorders | Lysosomal Acid Lipase Deficiency | Mabry Syndrome | Macrodactyly | Macrophage Activation Syndrome | Macrophagic Myofasciitis | Macular Corneal Dystrophy | Macular Corneal Dystrophy Type 1 | Macular Degeneration | Majeed Syndrome | Major Depression | Malaria | Malaria, Cerebral | Malignant Fibrous Histiocytoma | Malignant Peripheral Nerve Sheath Tumor | Malnutrition | Malonyl-CoA Decarboxylase Deficiency | Mandibuloacral Dysplasia With Type A Lipodystrophy | Mannosidase Deficiency Diseases | Maple Syrup Urine Disease | Marfan Syndrome | Marinesco-Sjogren Syndrome | Marshall-Smith Syndrome | Martsolf Syndrome | Mast Cell Leukemia | Mastitis | Maternally Inherited Diabetes And Deafness | McCune-Albright Syndrome | McKusick Type Metaphyseal Chondrodysplasia | McLeod Syndrome | Measles | Meckel-Gruber Syndrome | Meconium Ileus | Medium-chain Acyl-CoA Dehydrogenase Deficiency | Medulloblastoma | Meesmann Corneal Dystrophy | Megacystis-microcolon-intestinal Hypoperistalsis Syndrome | Megalencephaly | Megaloblastic Anemia | Meier-Gorlin Syndrome | Melanocytic Nevus | Melanoma | Melanoma, Malignant | Melanoma, Uveal | MELAS Syndrome | Meleda Disease | Melnick-Needles Syndrome | Membranous Nephropathy | Meniere's Disease | Meningeal Melanocytoma | Meningioma | Meningioma, Benign | Meningitis | Meningococcal Infections
