A Promising Drug Target: FOLR3 (FOLR3_HUMAN) (G2352)

Target Name: FOLR3

NCBI ID: G2352

A Promising Drug Target: FOLR3 (FOLR3_HUMAN)

Introduction

Folr3 (FOLR3_HUMAN) is a gene that encodes a protein known as human folate receptor alpha chain (FOLORe), which is a key regulator of cell growth and differentiation. The FOLORe gene has been identified as a potential drug target in the field of cancer and other diseases due to its involvement in various cellular processes, including cell signaling, DNA replication, and apoptosis.

History of Research

The study of FOLORe and its potential as a drug target began in the late 1990s, when researchers identified the gene as a cancer-specific gene that was highly expressed in various tissues, including the brain, spleen, and gastrointestinal tract. Subsequent studies have confirmed that FOLORe is involved in various cellular processes, including cell signaling, DNA replication, and apoptosis.

During the 2000s, researchers began to investigate the potential clinical applications of FOLORe as a drug target. They found that FOLORe was expressed in various types of cancer, including breast, ovarian, and colorectal cancer. Additionally, studies have shown that inhibiting FOLORe can lead to a reduction in cancer cell proliferation and survival.

Targeting FOLORe

Folr3 (FOLR3_HUMAN) is a unique drug target because of its unusual structure and the specific way it interacts with other molecules. FOLORe is a 22-kDa protein that consists of an N-terminus, a catalytic domain, and a C-terminus. The The catalytic domain is the region of the protein that contains the critical enzymes required for protein-protein interactions, while the N-terminus and C-terminus are involved in the protein's stability and interactions with other molecules.

One of the unique aspects of FOLORe is its ability to form a binary complex with other proteins. This means that two separate proteins can form a stable complex with FOLORe, which can lead to a more stable and active form of the protein. proteins that can form a binary complex with FOLORe is the protein p21 (T-cell kinase), which is known for its role in cell signaling and apoptosis.

In recent years, researchers have been interested in using small molecules, such as inhibitors, to target FOLORe. These inhibitors can either inhibit the interaction between FOLORe and p21 or inhibit the activity of FOLORe itself. Researchers have found that inhibitors can lead to a reduction in cancer cell proliferation and survival, which suggests that FOLORe may be an attractive drug target.

Current Theories

The exact mechanism of how FOLORe interacts with other proteins is not well understood, but several theories have been proposed to explain its unique properties. One theory is that FOLORe forms a binary complex with p21, which allows it to exert its full function as a protein . Another theory is that FOLORe interacts directly with the protein p53, which is a well-known regulator of apoptosis.

In addition to its interaction with p21 and p53, FOLORe has also been shown to interact with several other proteins, including the transcription factor p36, the protein S/N-acetylcytosine (SNAC) receptor, and the protein FBN1. These interactions may be important for FOLORe's functions in cell signaling and apoptosis.

Conclusion

Folr3 (FOLR3_HUMAN) is a gene that encodes a protein known as human folate receptor alpha chain (FOLORe). FOLORe has been identified as a potential drug target due to its involvement in various cellular processes, including cell signaling, DNA replication, and apoptosis. In recent years, researchers have been interested in using small molecules, such as inhibitors, to target FOLORe. These inhibitors can either inhibit the interaction between FOLORe and other proteins or inhibit the activity of FOLORe itself. Further research is needed to fully understand the unique properties of FOLORe and its potential as a drug target.

Protein Name: Folate Receptor Gamma

Functions: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. Isoform Short does not bind folate

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