FOXM1: Potential Cancer Drug Target (G2305)

Target Name: FOXM1

NCBI ID: G2305

FOXM1: Potential Cancer Drug Target

FOXM1, also known as HNF-3 or fork-head homolog 11, is a gene that encodes a protein involved in various cellular processes. The protein encoded by this gene is known asFOXM1, which is a key regulator of cell growth, development, and survival.FOXM1 plays a vital role in the regulation of cell proliferation, and it is known to be involved in the development and progression of many diseases, including cancer.

FOXM1 is a member of the HNF family, which includes several similar genes that encode proteins involved in the regulation of cell growth and differentiation. The HNF family is characterized by the presence of a nuclear factor of activated T cells (NFAT) domain in the protein sequence. This domain is known to play a critical role in the regulation of cellular processes, including cell growth, differentiation, and survival.

FOXM1 is expressed in many different tissues and cells throughout the body, including the liver, pancreas, and gastrointestinal tract. It is also highly expressed in many types of cancer, including breast, ovarian, and colorectal cancer. This suggests that FOXM1 may be an attractive drug target for cancer researchers, as targeting this protein may be a way to develop new and more effective therapies for cancer.

FOXM1 is involved in the regulation of many different cellular processes, including cell growth, differentiation, and survival. It is known to be involved in the development and progression of many diseases, including cancer.

One of the key functions of FOXM1 is its role in the regulation of cell proliferation.FOXM1 is known to play a vital role in the regulation of cell cycle progression, and it is involved in the regulation of the G1/S transition, which is a critical step in the cell cycle that involves the preparation of the cell for cell division.

FOXM1 is also involved in the regulation of cell differentiation and plasticity. It is known to be involved in the regulation of cell adhesion, and it is thought to play a role in the development of cancer stem cells.

FOXM1 is also involved in the regulation of cell survival. It is known to be involved in the regulation of apoptosis, which is a critical mechanism that helps the body to eliminate damaged or dysfunctional cells.

In conclusion, FOXM1 is a gene that encodes a protein involved in various cellular processes. The protein encoded by this gene is known asFOXM1, and it plays a vital role in the regulation of cell growth, development, and survival.FOXM1 is a potential drug target for cancer researchers, and targeting this protein may be a way to develop new and more effective therapies for cancer.

Protein Name: Forkhead Box M1

Functions: Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis (PubMed:19160488, PubMed:20360045). Plays a role in the control of cell proliferation (PubMed:19160488). Also plays a role in DNA break repair, participating in the DNA damage checkpoint response (PubMed:17101782). Promotes transcription of PHB2 (PubMed:33754036)

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