FRS2: A Protein Involved in Cell Signaling, Angiogenesis and Inflammation

Target Name: FRS2

NCBI ID: G10818

FRS2: A Protein Involved in Cell Signaling, Angiogenesis and Inflammation

FRS2 (FRS2_HUMAN) is a protein that is expressed in various tissues of the human body, including the brain, heart, and blood vessels. It is a member of the Fyn family of proteins, which are known for their role in cell signaling and intracellular signaling pathways.

FRS2 has been shown to play a role in the regulation of cell proliferation, differentiation, and survival. It has been shown to interact with a variety of protein partners, including the transcription factor PDGF-1, the oncogene transforming growth factor 2 (TGF-2), and the negative regulator p53.

FRS2 has also been shown to be involved in the regulation of angiogenesis, the process by which new blood vessels are formed. It has been shown to promote the formation of new blood vessels in response to the presence of angiotensin, a hormone that causes blood vessels to constrict.

FRS2 has also been shown to be involved in the regulation of inflammation. It has been shown to interact with the cytokine interleukin-1 (IL-1), and to contribute to the regulation of the immune response.

In addition to its role in cell signaling and angiogenesis, FRS2 has also been shown to be involved in the regulation of cellular processes that are important for maintaining cellular homeostasis. It has been shown to interact with the protein pH-regulator ATP-2, which is involved in the regulation of ion homeostasis and cell signaling.

FRS2 has also been shown to play a role in the regulation of protein synthesis and degradation. It has been shown to interact with the protein ubiquitin, which is involved in the degradation of damaged or unnecessary proteins.

In conclusion, FRS2 is a protein that has been shown to play a role in a variety of cellular processes that are important for maintaining cellular homeostasis and regulating cell signaling and angiogenesis. As a drug target or biomarker, FRS2 may be a promising target for the development of new therapeutic agents for a variety of diseases.

Protein Name: Fibroblast Growth Factor Receptor Substrate 2

Functions: Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1

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