Target Name: FUS
NCBI ID: G2521
Other Name(s): Heterogeneous nuclear ribonucleoprotein P2 | HNRNPP2 | FUS RNA binding protein, transcript variant 3 | Oncogene TLS | FUS variant 3 | Fus/tls-chop oncogene | FUS variant 1 | FUS1 | heterogeneous nuclear ribonucleoprotein P2 | oncogene FUS | oncogene TLS | RNA-binding protein FUS (isoform 1) | FUS RNA binding protein, transcript variant 4 | Fus-like protein | POMP75 | RNA-binding protein FUS | ALS6 | fused in sarcoma | TLS | translocated in liposarcoma protein | FUS-CHOP fusion protein | FUS RNA binding protein | FUS RNA binding protein, transcript variant 1 | 75 kDa DNA-pairing protein | altFUS | ETM4 | Translocated in liposarcoma protein | POMp75 | FUS_HUMAN | Fusion gene in myxoid liposarcoma | FUS-CHOP protein fusion | FUS variant 4 | Fus-like protein (isoform 3) | Oncogene FUS | fusion gene in myxoid liposarcoma | RNA-binding protein FUS (isoform 2) | fus-like protein

FUS: A Protein Potential Drug Target and Biomarker

FUS (Heterogeneous nuclear ribonucleoprotein P2) is a protein that is expressed in a variety of tissues throughout the body, including muscle, heart, and brain. It is a key component of the ribosome, which is the machine that cells use to synthesize proteins , and it is involved in the regulation of various cellular processes.

FUS has been identified as a potential drug target and biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and various functions make it an attractive target for researchers to study and develop new treatments.

One of the key reasons for the interest in FUS as a drug target is its role in the regulation of cell growth and division. FUS is a transcription factor, which means it helps cells turn on gene expression. It is known to play a role in the regulation of cell proliferation, and studies have suggested that it may be involved in the development of cancer.

In addition to its role in cell growth and division, FUS is also involved in the regulation of cell death. It has been shown to play a role in the regulation of apoptosis, which is a natural process that helps cells remove damaged or unnecessary proteins and prepare for cell death.

FUS has also been shown to be involved in the regulation of the immune system. Studies have suggested that it may play a role in the development of autoimmune disorders, such as rheumatoid arthritis and multiple sclerosis.

In addition to its potential uses as a drug target and biomarker, FUS is also of interest to researchers as a potential sample for studying disease. Its unique structure and various functions make it an attractive target for researchers to study and understand the underlying mechanisms of various diseases.

Overall, FUS is a protein that has the potential to be a valuable drug target and biomarker for a variety of diseases. Its unique structure and various functions make it an attractive target for researchers to study and develop new treatments. Further research is needed to fully understand its role in the regulation of cell growth and division, and to determine its potential as a drug target and biomarker.

Protein Name: FUS RNA Binding Protein

Functions: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity)

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