GABRE: A GPCR Involved in Neural Circuits and Various Diseases

Target Name: GABRE

NCBI ID: G2564

Other Name(s): Gamma-aminobutyric acid type A receptor subunit epsilon | GBRE_HUMAN | gamma-aminobutyric acid (GABA) A receptor, epsilon | gamma-aminobutyric acid type A receptor epsilon subunit | Gamma-aminobutyric acid receptor subunit epsilon | GABA(A) receptor subunit epsilon | OTTHUMP00000025892 | GABA(A) receptor, epsilon | gamma-aminobutyric acid type A receptor subunit epsilon | Gamma-aminobutyric acid (GABA) A receptor, epsilon precursor

GABRE: A GPCR Involved in Neural Circuits and Various Diseases

GABRE (Gamma-aminobutyric acid type A receptor subunit epsilon) is a G protein-coupled receptor (GPCR) that is expressed in many tissues and cells throughout the body. It is a key regulator of neural circuits and has been implicated in a wide range of physiological processes, including muscle contractions, neurotransmitter release, and pain perception.

GABRE is a transmembrane protein that consists of an extracellular domain, a transmembrane region, and an intracellular domain. The transmembrane region contains a GABA-binding site, which is the site where GABA (纬-aminobutyric acid) binds to the receptor. The intracellular domain contains a GABA-伪 hinge, which is responsible for the receptor's conformational changes upon GABA binding.

GABRE is involved in a wide range of physiological processes, including muscle contractions, neurotransmitter release, and pain perception. It is involved in the regulation of muscle tone and muscle contractions, and has been implicated in the development of muscle weakness and myopathies. GABRE has also been shown to play a role in the regulation of neurotransmitter release, including the release of pain-related neurotransmitters.

In addition to its role in neural circuits, GABRE has also been shown to have a variety of potential therapeutic applications. For example, GABRE has been shown to be a potential drug target for a variety of diseases, including chronic pain, neurodegenerative diseases, and psychiatric disorders.

GABRE has also been shown to be a potential biomarker for a variety of diseases. For example, GABRE has been shown to be decreased in individuals with major depressive disorder (MDD), and has been shown to be associated with increased risk of stroke in individuals with hypertension. Additionally, GABRE has been shown to be decreased in individuals with Alzheimer's disease, and has been shown to be associated with increased risk of developing this disease.

GABRE has also been shown to play a role in the regulation of various physiological processes, including blood pressure, heart rate, and body temperature. It has been shown to regulate the activity of ion channels in the heart and to play a role in the regulation of neurotransmitter release.

In conclusion, GABRE is a GPCR that is involved in a wide range of physiological processes and has been implicated in a variety of diseases. Its potential as a drug target and biomarker make it an attractive target for future research and clinical development. Further studies are needed to fully understand the role of GABRE in neural circuits and its potential therapeutic applications.

Protein Name: Gamma-aminobutyric Acid Type A Receptor Subunit Epsilon

Functions: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel

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