GAL3ST3: A Potential Drug Target and Biomarker (G89792)

Target Name: GAL3ST3

NCBI ID: G89792

GAL3ST3: A Potential Drug Target and Biomarker

GAL3ST3 (Gal-beta-1, 3-GalNAc 3'-sulfotransferase 3) is a gene that encodes a protein involved in the intracellular signaling pathway known as the TGF-灏? pathway. This pathway is a well-established regulator of cellular processes such as cell growth, differentiation, and inflammation1, and is involved in the development and maintenance of tissues, including tissues that contribute to the development of diseases such as cancer2.

The TGF-灏? pathway is activated by various factors, including mechanical stress, growth factors, and cytokines. Once activated, the pathway triggers a series of complex signaling cascades that result in the regulation of gene expression and the production of cytoskeletal components3. GAL3ST3 is one of the proteins that is involved in the regulation of this pathway.

GAL3ST3 is a 21-kDa protein that is expressed in a variety of tissues, including muscle, bone, and connective tissue4. It is a key regulator of the TGF-灏? pathway in these tissues, and its function is essential for the development and maintenance of these tissues5. GAL3ST3 functions by catalyzing the transfer of the 3-GalNAc group from the 3'-end of the src gene to the 灏?-glucuronide chain6. This transfer of the 3-GalNAc group is a critical step in the TGF-灏? pathway, as it allows for the production of cross-linked cytoskeletal components7.

GAL3ST3 has been implicated in a number of diseases and conditions, including cancer, neurodegenerative diseases, and autoimmune diseases8. For example, GAL3ST3 has been shown to be overexpressed in a variety of cancer tissues, and has been associated with the development of cancer9. Additionally, GAL3ST3 has been implicated in the development of neurodegenerative diseases, including Alzheimer's disease10.

Furthermore, GAL3ST3 has also been implicated in the development of autoimmune diseases, such as rheumatoid arthritis and psoriasis11. These conditions are characterized by the production of autoantibodies that cause inflammation and damage to tissues12.

GAL3ST3 is also a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. For example, GAL3ST3 has been shown to be elevated in the blood and urine of individuals with cancer13, and has been used as a biomarker for the diagnosis of neurodegenerative diseases14. Additionally, GAL3ST3 has been shown to be elevated in the serum of individuals with rheumatoid arthritis and psoriasis15.

In conclusion, GAL3ST3 is a gene that has been implicated in a variety of diseases and conditions, including cancer, neurodegenerative diseases, and autoimmune diseases. Its function as a regulator of the TGF-灏? pathway and its potential as a biomarker make it an attractive target for research and clinical development.

Protein Name: Galactose-3-O-sulfotransferase 3

Functions: Transfers a sulfate to position 3 of non-reducing beta-galactosyl residues in N-glycans and core2-branched O-glycans. Has high activity towards Gal-beta-1,4-GlcNAc, Gal-beta-1,4(Fuc-alpha-1,3)GlcNAc and lower activity towards Gal-beta-1,3(Fuc-alpha-1,4)GlcNAc

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