GAPT: A Protein Involved in GRB2 Signaling and Cell Survival (G202309)

Target Name: GAPT

NCBI ID: G202309

GAPT: A Protein Involved in GRB2 Signaling and Cell Survival

GAPT (GRB2 binding adaptor protein, transmembrane, transcript variant 4) is a protein that is expressed in various tissues and cells throughout the body. It is a transmembrane protein that is known to interact with the protein GRB2 (G protein-coupled receptor 2), which is a protein that is involved in a variety of cellular processes, including sensory perception and neurotransmission.

GAPT is a protein that is composed of 115 amino acid residues and has a calculated molecular weight of 13.9 kDa. It is expressed in a variety of tissues, including the brain, heart, and skeletal muscles. GAPT is also highly expressed in the placenta, which is a vital organ that plays a critical role in the development and maintenance of fetal tissue.

One of the unique features of GAPT is its ability to interact with GRB2. This interaction between GAPT and GRB2 is important for the function of the GRB2 protein, as it allows the protein to transmit signals from its receptor to the intracellular signaling pathway.

GAPT has been shown to play a role in a variety of cellular processes, including the regulation of neurotransmitter release, the modulation of pain perception, and the control of cell survival. For example, GAPT has been shown to interact with the neurotransmitter GABA, which is involved in the regulation of anxiety and stress. This interaction between GAPT and GABA suggests that GAPT may be involved in the regulation of neurotransmitter release and the modulation of brain function.

In addition to its role in neurotransmission, GAPT has also been shown to play a role in the regulation of cell survival. For example, GAPT has been shown to interact with the protein p53, which is a protein that is involved in the regulation of cell growth and apoptosis (programmed cell death). This interaction between GAPT and p53 suggests that GAPT may be involved in the regulation of cell survival and the modulation of cellular processes that are important for cell survival.

GAPT is also known to play a role in the regulation of pain perception. For example, GAPT has been shown to interact with the neurotransmitter nociceptin, which is involved in the regulation of pain perception. This interaction between GAPT and nociceptin suggests that GAPT may be involved in the regulation of pain perception and the modulation of cellular processes that are important for pain perception.

GAPT is also an attractive drug target due to its unique ability to interact with GRB2. This interaction between GAPT and GRB2 suggests that GAPT may be a useful target for the development of new drugs that are involved in the regulation of GRB2-mediated signaling pathways. Additionally, GAPT is highly expressed in various tissues, including the brain, heart, and skeletal muscles, which suggests that it may be a useful target for the development of drugs that are involved in the regulation of cellular processes in these tissues.

In conclusion, GAPT is a protein that is involved in a variety of cellular processes throughout the body. Its ability to interact with GRB2 makes it an attractive drug target for the development of new drugs that are involved in the regulation of GRB2-mediated signaling pathways. Additionally, GAPT is highly expressed in various tissues, including the brain, heart, and skeletal muscles, which suggests that it may be a useful target for the development of drugs that are involved in the regulation of cellular processes in these tissues. Further research is needed to fully understand the role of GAPT in cellular processes and its potential as a drug target.

Protein Name: GRB2 Binding Adaptor Protein, Transmembrane

Functions: Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity)

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