GAS6-AS1: A Potential Drug Target and Biomarker (G650669)
GAS6-AS1: A Potential Drug Target and Biomarker
GAS6-AS1, also known as GAS6 antisense RNA 1, is a non-coding RNA molecule that has been identified as a potential drug target and biomarker in various diseases, including cancer. Its unique structure and function make it an attractive target for researchers to study and develop new treatments.
GAS6-AS1 is a small RNA molecule that is approximately 200 nucleotides long. It is produced by RNA-mediated cleavage reaction and is transcribed from the RNA encoding the gene. GAS6-AS1 is an antisense RNA whose 5'-end interacts with the 3'-end of a GAS6 protein to form a GAS6-AS1-GAS6 structure. GAS6 is a conserved protein with conserved amino acid sequences in different organisms. The 3'-end of GAS6-AS1 contains a cap structure. The methyl group (CH3) in the cap structure can form a hydrogen bond with the carbonyl group (C=O) on the Glu215 residue of the GAS6 protein, thereby enhancing the GAS6-AS1-GAS6 structure. stability.
The function of GAS6-AS1 is mainly manifested in tumorigenesis and progression. Studies have shown that GAS6-AS1 is up-regulated in a variety of tumors, including lung cancer, liver cancer, breast cancer, etc. The expression level of GAS6-AS1 is positively correlated with tumor indicators such as tumor invasion ability, growth rate, and survival time. In addition, GAS6-AS1 is also associated with apoptosis and proliferation of tumor cells. Studies have shown that the expression level of GAS6-AS1 can regulate the proliferation of tumor cells by regulating cell cycle, inducing apoptosis and other mechanisms.
Because GAS6-AS1 plays an important role in tumorigenesis and progression, it is regarded as a potential drug target. The expression level of GAS6-AS1 can be regulated through multiple pathways, including regulating gene expression, epigenetic modification, etc. These regulatory mechanisms make GAS6-AS1 a potential drug target.
In addition, GAS6-AS1 can also serve as a biomarker. The expression level of GAS6-AS1 in tumor patients is positively correlated with tumor indicators such as tumor invasion ability, growth rate, and survival period. Therefore, GAS6-AS1 can be used as a tumor biomarker. By detecting the expression level of GAS6-AS1, doctors can evaluate the condition of tumor patients and provide patients with more accurate diagnosis and treatment plans.
GAS6-AS1, as a non-coding RNA molecule, has unique structure and function. By studying GAS6-AS1, we can gain a deeper understanding of the regulatory mechanism of RNA splicing reactions and provide new ideas and methods for tumor treatment. At the same time, GAS6-AS1, as a potential drug target and biomarker, also has broad application prospects. With the deepening of research, GAS6-AS1 will play a more important role in tumor treatment.
Protein Name: GAS6 Antisense RNA 1
More Common Targets
GAS7 | GAS8 | GAS8-AS1 | GASAL1 | GASK1A | GASK1B | GASK1B-AS1 | GAST | GATA1 | GATA2 | GATA2-AS1 | GATA3 | GATA3-AS1 | GATA4 | GATA5 | GATA6 | GATA6-AS1 | GATAD1 | GATAD2A | GATAD2B | GATB | GATC | GATD1 | GATD1-DT | GATD3 | GATM | GATOR1 Complex | GAU1 | GBA1 | GBA2 | GBA3 | GBAP1 | GBE1 | GBF1 | GBGT1 | GBP1 | GBP1P1 | GBP2 | GBP3 | GBP4 | GBP5 | GBP6 | GBP7 | GBX1 | GBX2 | GC | GCA | GCAT | GCC1 | GCC2 | GCC2-AS1 | GCDH | GCFC2 | GCG | GCGR | GCH1 | GCHFR | GCK | GCKR | GCLC | GCLM | GCM1 | GCM2 | GCN1 | GCNA | GCNT1 | GCNT1P3 | GCNT2 | GCNT3 | GCNT4 | GCNT7 | GCOM1 | GCSAM | GCSAML | GCSAML-AS1 | GCSH | GCSHP3 | GCSIR | GDA | GDAP1 | GDAP1L1 | GDAP2 | GDE1 | GDF1 | GDF10 | GDF11 | GDF15 | GDF2 | GDF3 | GDF5 | GDF6 | GDF7 | GDF9 | GDI1 | GDI2 | GDI2P1 | GDNF | GDNF Family Receptor alpha | GDNF-AS1 | GDPD1
