GAS1: A Protein Implicated in Cancer and Neurodegenerative Diseases
GAS1: A Protein Implicated in Cancer and Neurodegenerative Diseases
GAS1, or Growth arrest specific 1, is a protein that is expressed in a variety of tissues throughout the body. It is a key regulator of cell growth and has been implicated in a number of diseases, including cancer. As a drug target, GAS1 has the potential to be developed into a treatment for a variety of conditions.
GAS1 was first identified in the late 1990s as a protein that was expressed in a variety of tissues, including brain, heart, and muscle. It is characterized by a unique domain structure that is specific to GAS1. This domain is composed of a Rossmann- fold, a structural motif that is commonly found in proteins that play important roles in cell signaling.
GAS1 functions as a negative regulator of cell growth. It inhibits the activity of the protein kinase kinase, which is a key enzyme that promotes cell growth. This inhibition of cell growth can lead to the arrest of cell proliferation and the onset of a variety of diseases, including cancer.
GAS1 has also been shown to play a role in a number of other cellular processes, including cell adhesion, migration, and the regulation of ion channels. It is also involved in the regulation of cellular transport and has been implicated in the development of neurodegenerative diseases.
As a drug target, GAS1 has the potential to be developed into a treatment for a variety of conditions. For example, it has been shown to be a potential therapeutic target for cancer, including breast, ovarian, and colorectal cancers. In addition, GAS1 has been shown to be involved in the development of neurodegenerative diseases, including Alzheimer's and Parkinson's diseases.
In addition to its potential as a drug target, GAS1 also has the potential as a biomarker. Its expression has been shown to be elevated in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This makes it a promising candidate for use as a diagnostic or monitoring tool in these conditions.
GAS1 is also a potential target for small molecules. Its function as a negative regulator of cell growth makes it a potential target for drugs that are designed to inhibit cell proliferation. This has the potential to be a useful approach for the development of anti-cancer drugs.
In conclusion, GAS1 is a protein that is expressed in a variety of tissues throughout the body and has been implicated in a number of diseases. As a drug target, it has the potential to be developed into a treatment for a variety of conditions, including cancer and neurodegenerative diseases. Its function as a negative regulator of cell growth also makes it a potential target for small molecules. Further research is needed to fully understand the role of GAS1 in these conditions and to develop safe and effective treatments.
Protein Name: Growth Arrest Specific 1
Functions: Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells
More Common Targets
GAS1RR | GAS2 | GAS2L1 | GAS2L2 | GAS2L3 | GAS5 | GAS6 | GAS6-AS1 | GAS7 | GAS8 | GAS8-AS1 | GASAL1 | GASK1A | GASK1B | GASK1B-AS1 | GAST | GATA1 | GATA2 | GATA2-AS1 | GATA3 | GATA3-AS1 | GATA4 | GATA5 | GATA6 | GATA6-AS1 | GATAD1 | GATAD2A | GATAD2B | GATB | GATC | GATD1 | GATD1-DT | GATD3 | GATM | GATOR1 Complex | GAU1 | GBA1 | GBA2 | GBA3 | GBAP1 | GBE1 | GBF1 | GBGT1 | GBP1 | GBP1P1 | GBP2 | GBP3 | GBP4 | GBP5 | GBP6 | GBP7 | GBX1 | GBX2 | GC | GCA | GCAT | GCC1 | GCC2 | GCC2-AS1 | GCDH | GCFC2 | GCG | GCGR | GCH1 | GCHFR | GCK | GCKR | GCLC | GCLM | GCM1 | GCM2 | GCN1 | GCNA | GCNT1 | GCNT1P3 | GCNT2 | GCNT3 | GCNT4 | GCNT7 | GCOM1 | GCSAM | GCSAML | GCSAML-AS1 | GCSH | GCSHP3 | GCSIR | GDA | GDAP1 | GDAP1L1 | GDAP2 | GDE1 | GDF1 | GDF10 | GDF11 | GDF15 | GDF2 | GDF3 | GDF5 | GDF6 | GDF7
