GARRE1: A Potential Drug Target and Biomarker (G9710)

Target Name: GARRE1

NCBI ID: G9710

Other Name(s): Granule associated Rac and RHOG effector 1 | KIAA0355 | GRRE1_HUMAN | Granule associated Rac and RHOG effector protein 1 | granule associated Rac and RHOG effector 1

GARRE1: A Potential Drug Target and Biomarker

GARRE1, also known as Granule associated Rac and RHOG effector 1, is a protein that plays a crucial role in the regulation of cell growth and differentiation. Discovered in 2015, GARRE1 has since been shown to be involved in a wide range of physiological processes, including cell signaling, cytoskeletal organization, and chromatin dynamics. As a result, GARRE1 has potential as a drug target and biomarker.

The GARRE1 protein is composed of 195 amino acid residues and has a calculated molecular mass of 21 kDa. It is located at the center of the microtubules and is involved in the regulation of microtubule dynamics and stability. GARRE1 interacts with a variety of protein partners, including microtubule-associated proteins (MAPs), kinesins, and microtubule-associated nucleotides (MANs).

GARRE1 has been shown to play a role in a wide range of cellular processes, including cell signaling, cytoskeletal organization, and chromatin dynamics. For example, GARRE1 has been shown to be involved in the regulation of cell cycle progression, where it promotes the G1 phase and the G2/M phases by increasing the stability of microtubules. Additionally, GARRE1 has been shown to be involved in the regulation of actin dynamics, where it promotes the movement of actin filaments by increasing the stability of microtubules.

GARRE1 has also been shown to play a role in the regulation of chromatin dynamics. For example, GARRE1 has been shown to interact with the protein NCPase, which is involved in the regulation of DNA replication and repair. This interaction between GARRE1 and NCPase suggests that GARRE1 may be involved in the regulation of chromatin dynamics during these processes.

In addition to its role in cellular signaling, GARRE1 has also been shown to be involved in the regulation of cytoskeletal organization. For example, GARRE1 has been shown to interact with the protein Xenophos, which is involved in the regulation of cytoskeletal organization. This interaction between GARRE1 and Xenophos suggests that GARRE1 may be involved in the regulation of cytoskeletal organization during these processes.

GARRE1 has also been shown to play a role in the regulation of cell survival. For example, GARRE1 has been shown to interact with the protein p53, which is involved in the regulation of cell apoptosis. This interaction between GARRE1 and p53 suggests that GARRE1 may be involved in the regulation of cell survival during these processes.

GARRE1 has been shown to play a role in the regulation of tissue repair and regeneration. For example, GARRE1 has been shown to interact with the protein T-cell factor (TGF-β), which is involved in the regulation of tissue repair and regeneration. This interaction between GARRE1 and TGF-β suggests that GARRE1 may be involved in the regulation of tissue repair and regeneration during these processes.

GARRE1 has also been shown to play a role in the regulation of neurodegeneration. For example, GARRE1 has been shown to interact with the protein 尾-tubulin, which is involved in the regulation of neurodegeneration. This interaction between GARRE1 and 尾-tubulin suggests that GARRE1 may be involved in the regulation of neurodegeneration during these processes.

GARRE1 has been shown to play a role in the regulation of cancer progression. For example, GARRE1 has been shown to interact with the protein

Protein Name: Granule Associated Rac And RHOG Effector 1

Functions: Acts as an effector of RAC1 (PubMed:31871319). Associates with CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation (PubMed:29395067). May also play a role in miRNA silencing machinery (PubMed:29395067)

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