GAGE12H: A Potential Drug Target and Biomarker for Neurodegenerative Diseases and Cancer

Target Name: GAGE12H

NCBI ID: G729442

Other Name(s): GG12H_HUMAN | G antigen 12H | GAGE-12H

GAGE12H: A Potential Drug Target and Biomarker for Neurodegenerative Diseases and Cancer

GAGE12H (GG12H_HUMAN), a glycoprotein gene located on chromosome 12, is a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its function and interaction with the body have been extensively studied, providing valuable insights into the pathophysiology and therapeutic potential of these diseases.

GAGE12H is a member of the G protein-coupled receptor (GPCR) family, which is a large family of transmembrane proteins that play a crucial role in cellular signaling. GPCR family members are involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling. GAGE12H is specifically characterized by its unique genetic structure, including an exonic splice variant and a variable number of exons at its introns.

GAGE12H has been implicated in various diseases and conditions, including neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. These diseases are characterized by the progressive loss of brain cells and neurotransmitter synthesis, leading to the development of cognitive and motor impairments. shown to play a role in the pathophysiology of these diseases, with increased expression of GAGE12H being observed in the brains of individuals with neurodegenerative disorders.

In addition to its involvement in neurodegenerative diseases, GAGE12H has also been implicated in cancer. GPCR signaling has been shown to promote the growth and survival of cancer cells, and GAGE12H has been reported to be involved in various cancer types. For example, GAGE12H has has been shown to be overexpressed in various types of cancer, including breast, lung, and colorectal cancer.

Furthermore, GAGE12H has also been investigated as a potential biomarker for cancer. Gage12H has been shown to be expressed in various types of cancer cells, including cancer stem cells, and has been used as a marker for cancer diagnosis and monitoring. For example, GAGE12H has been used as a biomarker in combination with other genes, such as the gene PDGF-R, to predict the prognosis of cancer patients.

GAGE12H has also been studied for its potential therapeutic potential. GPCR signaling has been shown to be sensitive to small molecules and other therapeutic agents, and GAGE12H has been targeted with various compounds, including small molecules, peptides, and antibodies. For example, GAGE12H has has been shown to be sensitive to inhibitors of the GPCR signaling pathway, including small molecules such as curcumin and benzotrional.

In addition to its potential therapeutic applications, GAGE12H has also been studied for its potential as a drug target. GPCR signaling has been shown to be involved in various physiological processes, including sensory perception, neurotransmission, and hormone signaling. Therefore, GAGE12H is a potential drug target for various diseases, including neurodegenerative diseases and cancer.

GAGE12H has been shown to be involved in the regulation of various cellular processes, including cell adhesion, migration, and survival. For example, Gage12H has been shown to be involved in the regulation of cell adhesion, as it has been shown to interact with the cell adhesion molecule E-cadherin. Additionally, Gage12H has been shown to be involved in the regulation of cell migration, as it has been shown to interact with the migratory protein Twi-2.

Gage12H has also been shown to play a role in the regulation of various signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cellular processes such as cell growth, differentiation, and survival, and is a key factor in the development and progression of many diseases, including neurodegenerative diseases and cancer.

In conclusion, GAGE12H is a GPCR-coupled receptor that has been implicated in various diseases and conditions, including neurodegenerative diseases and cancer. Its function and interaction with the body have been extensively studied, providing valuable insights into the pathophysiology and therapeutic potential of these diseases . Further research is needed to fully understand the role of GAGE12H in the regulation of cellular processes and its potential as a drug target.

Protein Name: G Antigen 12H

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