FZD9: A Potential Drug Target and Biomarker (G8326)

Target Name: FZD9

NCBI ID: G8326

FZD9: A Potential Drug Target and Biomarker

Fundamental Genomics and Development

FZD9 is a gene that encodes a protein known as fz-9. FZD9 is a key regulator of the actinin complex, a protein that is involved in many important cellular processes. Discovered in 2008, fz-9 has since been shown to play a crucial role in the regulation of cell division, and has been linked to the development of various diseases, including cancer. As a result, FZD9 has emerged as a promising drug target and biomarker for a variety of diseases.

The actinin complex is a protein that is composed of multiple subunits that are involved in the regulation of cell division. The subunits of actinin include the protein N-terminal actinin, the protein M-terminal actinin, and the protein C-terminal actinin. These proteins work together to form a complex that is involved in the regulation of cell division by controlling the movement of the microtubules that transport the chromosomes during cell division.

FZD9 is a key regulator of the actinin complex. It is a protein that is expressed in high levels in many different types of cells and is involved in the regulation of cell division. FZD9 has been shown to play a crucial role in the regulation of the actinin complex by controlling the stability of the microtubules that transport the chromosomes.

One of the key functions of FZD9 is to regulate the stability of the microtubules that transport the chromosomes. This is done by controlling the level of the protein K-associated protein 2 (KAP-2), which is a negative regulator of the microtubules. FZD9 has been shown to interact with KAP-2 and to regulate the level of KAP-2 in the cell.

FZD9 has also been shown to play a role in the regulation of cell growth. It is involved in the regulation of the cell cycle by controlling the movement of the chromosomes during cell division. This is done by regulating the level of the protein p21, which is a tumor suppressor protein that is involved in the regulation of the cell cycle.

In addition to its role in cell division, FZD9 has also been shown to play a role in the regulation of cell death. It is involved in the regulation of apoptosis, which is a natural process that helps to remove damaged or dysfunctional cells from the body. FZD9 has been shown to interact with the protein Bcl-2 and to regulate the level of Bcl-2 in the cell.

FZD9 has also been shown to play a role in the regulation of inflammation. It is involved in the regulation of the immune response by controlling the movement of immune cells during inflammation. FZD9 has been shown to interact with the protein NF-kappa-B and to regulate the level of NF-kappa-B in the cell.

FZD9 has also been shown to play a role in the regulation of pain. It is involved in the regulation of the pain response by controlling the movement of pain-sensitive neurons during pain. FZD9 has been shown to interact with the protein TrkB and to regulate the level of TrkB in the cell.

In conclusion, FZD9 is a protein that is involved in the regulation of many different cellular processes. It has been shown to play a crucial role in the regulation of cell division, cell growth, apoptosis, inflammation, and pain. As a result, FZD9 has emerged as a promising drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of FZD9 in these processes and to develop effective treatments for the diseases that are associated with it.

Protein Name: Frizzled Class Receptor 9

Functions: Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity)

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