GABBR2: Key Regulator of Sensory Perception and Cell Survival

Target Name: GABBR2

NCBI ID: G9568

GABBR2: Key Regulator of Sensory Perception and Cell Survival

GABBR2 (G protein-coupled receptor 2) is a protein that is expressed in many different tissues throughout the body. It is a member of the G protein-coupled receptor family, which is a large superfamily of transmembrane proteins that play an important role in cellular signaling. GABBR2 is involved in a wide range of physiological processes, including sensory perception, neurotransmitter signaling, and cell survival.

GABBR2 is a key regulator of sensory perception. It is expressed in the sensory neurons and is involved in the transmission of signals from the sensory nervous system to the brain. GABBR2 plays a role in the regulation of pain, anxiety, and other forms of sensory irritation.

GABBR2 is also involved in neurotransmitter signaling. It is a receptor for several neurotransmitters, including GABA, serotonin, and dopamine. GABBR2 plays a critical role in the regulation of neurotransmitter signaling, and dysregulation of GABBR2 has been implicated in a wide range of neuropsychiatric and neurological disorders.

In addition to its role in sensory perception and neurotransmission, GABBR2 is also involved in cell survival. It has been shown to play a role in the regulation of cell proliferation and has been implicated in the development and progression of several types of cancer.

GABBR2 is a drug target that has been targeted by several research groups in recent years. Studies have shown that modulation of GABBR2 activity can have a wide range of effects on cellular behavior, including the regulation of pain perception, neurotransmission, and cell survival.

One of the most promising aspects of GABBR2 as a drug target is its involvement in the regulation of pain. Pain is a complex subjective experience that is highly subjective and difficult to study. However, GABBR2 has been shown to play a critical role in the regulation of pain perception and may serve as a useful target for the development of pain therapies.

GABBR2 has been shown to play a role in the regulation of neurotransmission, including the regulation of GABAergic neurotransmission. GABA is a neurotransmitter that is involved in the regulation of a wide range of cellular processes, including pain perception, anxiety, and neurotransmission. GABBR2 has been shown to play a role in the regulation of GABAergic neurotransmission, which may be relevant to the treatment of disorders that are characterized by hyperagitation or anxiety.

In addition to its involvement in pain perception and neurotransmission, GABBR2 has also been shown to play a role in the regulation of cell survival. Several studies have shown that GABBR2 is involved in the regulation of cell proliferation and has been implicated in the development and progression of several types of cancer. Therefore, targeting GABBR2 may be a useful approach for the development of anti-cancer therapies.

GABBR2 is also involved in the regulation of sensory perception. It is a receptor for several neurotransmitters, including GABA, serotonin, and dopamine, and has been shown to play a critical role in the regulation of sensory perception. Therefore, targeting GABBR2 may be a useful approach for the development of therapies that target sensory perception.

In conclusion, GABBR2 is a protein that is involved in a wide range of physiological processes. It is a key regulator of sensory perception, neurotransmission, and cell survival, and has been implicated in the development and progression of several types of cancer. As a drug target, GABBR2 is a promising target for the development of therapies that target a wide range of cellular processes. Further research is needed to fully understand the role of GABBR2 in

Protein Name: Gamma-aminobutyric Acid Type B Receptor Subunit 2

Functions: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10075644, PubMed:10773016, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644, PubMed:9872744, PubMed:10906333, PubMed:10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9872744, PubMed:22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed:9872316, PubMed:10075644, PubMed:9872744, PubMed:22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable)

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