GABARAPL3: A Potential Drug Target and Biomarker for Psychiatric Disorders

Target Name: GABARAPL3

NCBI ID: G23766

Other Name(s): ATG8D | GABA type A receptor associated protein like 3 pseudogene

GABARAPL3: A Potential Drug Target and Biomarker for Psychiatric Disorders

GABARAPL3 (ATG8D), a gene located on chromosome 16, has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders. The GABARAPL3 gene encodes a protein that is involved in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time.

Initial studies have shown that individuals with certain genetic variations in the GABARAPL3 gene are at increased risk for developing symptoms of depression, anxiety, and other psychiatric disorders. For example, individuals with the GABARAPL3 rs7042 variant were found to have an increased risk of developing major depressive disorder (MDD) and anxiety disorders.

In addition to its potential role in psychiatric disorders, GABARAPL3 has also been shown to be involved in the development of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. Studies have shown that individuals with certain genetic variations in the GABARAPL3 gene are at increased risk for developing these debilitating conditions.

GABARAPL3 is also a potential biomarker for various psychiatric disorders. For example, individuals with major depressive disorder (MDD) are often characterized by reduced levels of the protein brain-derived neurotrophic factor (BDNF), a protein that is involved in the maintenance of brain health. Similarly, individuals with anxiety disorders are often characterized by reduced levels of the protein serotonin, which is involved in the regulation of mood and anxiety.

In conclusion, GABARAPL3 is a gene that has the potential to be a drug target for various psychiatric and neurological disorders. Further research is needed to fully understand the role of GABARAPL3 in these conditions, as well as its potential as a biomarker for these disorders. By investigating the functions of GABARAPL3 and its potential as a drug and biomarker, researchers may be able to develop new treatments for these debilitating conditions.

Protein Name: GABA Type A Receptor Associated Protein Like 3 Pseudogene

Functions: Ubiquitin-like modifier involved in autophagosome formation. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (By similarity)

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