FZD10: A Potential Drug Target and Biomarker for Multiple Diseases

Target Name: FZD10

NCBI ID: G11211

Other Name(s): frizzled 10, seven transmembrane spanning receptor | CD350 | FZ-10 | frizzled class receptor 10 | Frizzled-10 | FZD10_HUMAN | FzE7 | Frizzled 10 | Fz10 | Frizzled class receptor 10 | frizzled homolog 10 | Fz-10 | hFz10 | frizzled family receptor 10

FZD10: A Potential Drug Target and Biomarker for Multiple Diseases

FZD10, also known as Frizzled 10, is a protein that is expressed in various tissues throughout the body. It is a member of the frizzled family of transmembrane proteins, which are characterized by the presence of a frizzled domain in their extracellular domain. The frizzled domain is known for its ability to interact with various signaling molecules, including TGF-β, Wnt, and Notch.

FZD10 is a seven transmembrane spanning receptor, which means that it spans the entire cell membrane and is involved in multiple membrane-spanning interactions. This type of receptor is responsible for cell-cell and cell-extracellular signaling, as well as the regulation of cellular processes such as cell growth, differentiation, and survival.

FZD10 has been identified as a potential drug target and may be a biomarker for various diseases. Its role in signaling cell-cell interactions has been implicated in a number of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of FZD10 is its role in cell-cell signaling. It has been shown to play a role in the regulation of cell proliferation and differentiation, as well as the development of cancer. For example, studies have shown that FZD10 is highly expressed in various types of cancer, including breast, lung, and ovarian cancer. Additionally, experiments have shown that inhibiting FZD10 can lead to a reduction in cancer cell proliferation.

FZD10 is also involved in the regulation of cell survival. Studies have shown that FZD10 plays a role in the regulation of cell survival by promoting the production of Bcl-2, a protein that can prevent cell death. Additionally, FZD10 has been shown to interact with the protein p53, which is also involved in cell survival regulation.

FZD10 has also been implicated in the regulation of neurodegenerative diseases. Studies have shown that FZD10 is expressed in the brains of individuals with neurodegenerative diseases, including Alzheimer's and Parkinson's disease. Additionally, experiments have shown that FZD10 is involved in the regulation of neurodegenerative disease by interacting with the protein Tau.

FZD10 may also be a biomarker for autoimmune disorders. Studies have shown that FZD10 is expressed in the tissues of individuals with a variety of autoimmune disorders, including rheumatoid arthritis, lupus, and multiple sclerosis. Additionally, experiments have shown that FZD10 is involved in the regulation of autoimmune disease by interacting with the protein PD-L1.

In conclusion, FZD10 is a protein that is involved in multiple cellular processes that are important for cell survival and regulation. Its role in cell-cell and cell-extracellular signaling, as well as its involvement in the regulation of cancer, neurodegenerative diseases, and autoimmune disorders make it a potential drug target and biomarker. Further research is needed to fully understand the role of FZD10 in these processes and to develop effective treatments for these diseases.

Protein Name: Frizzled Class Receptor 10

Functions: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable)

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