FUT8: A Promising Drug Target for Cancer and Other Diseases (G2530)

Target Name: FUT8

NCBI ID: G2530

FUT8: A Promising Drug Target for Cancer and Other Diseases

Fucosyltransferase 8 (FUT8) is a enzyme involved in the transfer of fucose units from the cell surface to the intracellular matrix (ECM) during cell-cell fusion. It is a critical enzyme in the process of cell-cell adhesion and cell-cell signaling, and is involved in various cellular processes including embryonic development, tissue repair, and cancer progression.

Recent studies have identified FUT8 as a potential drug target for various diseases, including cancer. One of the main reasons for its potential as a drug target is its involvement in the regulation of cell-cell adhesion, which is a critical factor in the development and progression of many diseases, including cancer.

FUT8 is a member of the fucoside 6-尾 family, which includes several enzymes involved in the transfer of fucose units from the cell surface to the ECM. These enzymes play a crucial role in the regulation of cell-cell adhesion, as well as the formation of tight junctions and other structures that help to maintain tissue structure and prevent the loss of cell-cell contact.

One of the key functions of FUT8 is its role in the regulation of cell-cell adhesion. This is done through the formation of tight junctions, which are specialized structures that help to maintain the integrity of the intercellular space and prevent the loss of cell-cell contact. FUT8 is involved in the transfer of fucose units to the cell surface, which is necessary for the formation of tight junctions.

In addition to its role in cell-cell adhesion, FUT8 is also involved in the regulation of other cellular processes that are important for the development and progression of many diseases, including cancer. For example, recent studies have shown that FUT8 is involved in the regulation of cell cycle progression, and that its expression is often decreased in cancer cells.

FUT8 has also been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels are formed to supply oxygen and nutrients to the growing body. This is important for the development of many diseases, including cancer, where the growth of new blood vessels is often a key factor in the disease progression.

FUT8 is also involved in the regulation of inflammation, which is a critical part of the immune response and can contribute to the development and progression of many diseases.

In conclusion, FUT8 is a highly promising drug target for various diseases, including cancer. Its involvement in the regulation of cell-cell adhesion, tight junction formation, cell cycle progression, angiogenesis, and inflammation makes it an attractive target for small molecules that can inhibit its activity. Further research is needed to fully understand the role of FUT8 as a drug target and to develop effective treatments for a variety of diseases.

Protein Name: Fucosyltransferase 8

Functions: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans

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