FUZ: A Potential Drug Target and Biomarker for Protein Fuzzy Homolog (ISO Form 1)

Target Name: FUZ

NCBI ID: G80199

FUZ: A Potential Drug Target and Biomarker for Protein Fuzzy Homolog (ISO Form 1)

Introduction

Protein fuzzy homolog (ISO Form 1), also known as FUZ, is a unique protein that has been identified in various organisms as having potential drug targets and biomarkers. FUZ is a member of the superfamily of N-terminal domain fuzzy protein, is A class of evolutionarily conserved proteins that can be found in a variety of organisms. In this article, we will discuss the properties of FUZ, its potential as a drug target and its application as a biomarker.

Nature of FUZ

FUZ is a 21.1 kDa polypeptide that contains a conserved cysteine 鈥嬧?媟esidue at its N-terminus, and its unique structural features make it an attractive research object. The N-terminus of FUZ contains a secondary domain composed of two interacting helical structural units. These helical building blocks are composed of a central beta helix that interacts with another helix through an outer alpha helix. In addition, the N-terminus of FUZ also contains a conserved lysine residue, which can be used as a research target for protein-protein interactions.

The role of FUZ in tumors

Studies have shown that FUZ is expressed in a variety of tumors, including lung cancer, liver cancer, breast cancer, and ovarian cancer. At the same time, the expression level of FUZ is positively correlated with tumor growth and invasion capabilities. In addition, the expression level of FUZ is also related to the survival rate of tumor patients. These findings suggest that FUZ may be a potential drug target.

Potential of FUZ as a drug target

As a drug target, FUZ has multiple potential mechanisms of action. First, FUZ can serve as a regulator of tumor cell growth and metastasis. Since FUZ is highly expressed in tumors, the growth and metastasis of tumor cells can be inhibited by inhibiting the function of FUZ. Secondly, FUZ can serve as a target for immune escape. FUZ can inhibit immune cells from killing tumors, thereby allowing tumor cells to evade immune surveillance. Finally, FUZ can serve as a target for drug therapy. By targeting the function and structure of FUZ, more effective drugs can be designed.

The application prospects of FUZ as a biomarker

FUZ can not only be used as a drug target, but also has application prospects as a biomarker. Since FUZ is expressed in a variety of organisms, it can be used as a widely used biomarker. For example, in cancer research, FUZ can be used as a marker in tumor tissue to assess the rate of tumor growth and metastasis. In addition, FUZ can also be used as a biomarker to detect drug efficacy. By measuring the expression level of FUZ, the killing effect of drugs on tumors can be evaluated, thereby providing more effective treatment options for tumor patients.

in conclusion

In summary, FUZ is a protein with potential drug target potential and biomarker application prospects. By further studying the structure and function of FUZ, we can better understand the role of FUZ in the organism and provide more effective treatment options for tumor patients.

Protein Name: Fuzzy Planar Cell Polarity Protein

Functions: Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity)

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