Stabilizer of Axonemal Microtubules (G283726)

Target Name: SAXO2

NCBI ID: G283726

Stabilizer of Axonemal Microtubules

SAXO2, or Stabilizer of Axonemal Microtubules 2, is a protein that plays a crucial role in the stability of microtubules in the axonemes of plants. It is a member of the microtubule-associated protein (MAP) family and is highly expressed in the Arabidopsis thaliana axonemes. SAXO2 functions as a stabilizer of microtubules by interacting with the alpha-tubulin protein and preventing its depolymerization.

The MAP family is a group of proteins that are involved in the regulation of microtubule dynamics and stability. These proteins have been implicated in a wide range of cellular processes, including cell division, intracellular transport, and cell signaling. The alpha-tubulin protein is a key component of microtubules and is involved in their stability. It is composed of four subunits that form a ring-shaped structure around the axonemes. The alpha-tubulin protein can interact with various stabilizers, including SAXO2, to maintain microtubule stability.

SAXO2 is a 21-kDa protein that is highly expressed in the axonemes of Arabidopsis thaliana. It is localized to the centromeric region of the axonemes and interacts with the alpha-tubulin protein to prevent its depolymerization. The interaction between SAXO2 and alpha-tubulin is critical for the stability of microtubules. Depolymerization of microtubules can have a negative impact on the efficiency of various cellular processes, including cell signaling and intracellular transport.

SAXO2 has been shown to play a role in regulating microtubule dynamics in various organisms. For example, it has been shown to play a role in regulating the assembly and disassembly of microtubules in the cucumber plant. In addition, SAXO2 has been shown to be involved in the regulation of cell division in the yeast plant.

Despite its importance for microtubule dynamics, SAXO2 is not yet a drug target or biomarker. There is a need for further research to fully understand the role of SAXO2 in the regulation of microtubule dynamics and to explore its potential as a drug or biomarker.

In conclusion, SAXO2 is a protein that plays a crucial role in the stability of microtubules in the axonemes of plants. It is a member of the MAP family and functions as a stabilizer of microtubules by interacting with the alpha-tubulin protein. Further research is needed to fully understand the role of SAXO2 in the regulation of microtubule dynamics and to explore its potential as a drug or biomarker.

Protein Name: Stabilizer Of Axonemal Microtubules 2

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