IGHV3-29: A Non-Coding RNA Regulating Immune Response (G28440)

Target Name: IGHV3-29

NCBI ID: G28440

Other Name(s): IGHV329 | immunoglobulin heavy variable 3-29 (pseudogene) | 3-29P | Immunoglobulin heavy variable 3-29 (pseudogene)

IGHV3-29: A Non-Coding RNA Regulating Immune Response

IGHV3-29 (IGHV329) is a short non-coding RNA (ncRNA) that is expressed in various tissues of the human body. It is a part of the IGHV family, which consists of four subfamilies: IGHV1-3, IGHV3-5, IGHV6-7, and IGHV8-9. IGHV3-29 is one of the members of the IGHV3 subfamily.

IGHV3-29 is a small RNA molecule that contains 29 amino acid residues. It is primarily expressed in the brain, where it is involved in the regulation of various cellular processes. IGHV3-29 is a non-coding RNA, which means that it does not have a defined coding sequence. Instead, it is made up of a sequence of ncRNA bases that are processed by the cell's RNA-proteasome system to produce a protein.

The IGHV3 subfamily is a group of non-coding RNAs that are involved in the regulation of the immune response. These RNAs are characterized by the presence of a specific stem-loop structure, which is a common motif found in many proteins. The IGHV3 subfamily is named after the IGHV3 gene, which is located on chromosome 14 and encodes the protein IGHV3.

IGHV3-29 is a member of the IGHV3 subfamily because it has the same stem-loop structure as other members of the subfamily. The stem-loop is a structural element that is found in the middle of the ncRNA molecule and is responsible for the stability and translation of the RNA into a protein.

IGHV3-29 has been shown to play a role in the regulation of the immune response. For example, studies have shown that IGHV3-29 is involved in the development of CD4+ T cells, which are a crucial part of the immune system. IGHV3-29 has also been shown to regulate the activity of the enzyme NF-kappa-B, which is involved in the regulation of various cellular processes.

In addition to its role in the immune response, IGHV3-29 may also be a drug target or biomarker. For example, studies have shown that IGHV3-29 can be downregulated in various diseases, including cancer and neurodegenerative diseases. This suggests that IGHV3-29 may be a useful target for new therapies. Additionally, IGHV3-29 has been shown to be involved in the regulation of various cellular processes, which may make it a useful biomarker for certain diseases.

Overall, IGHV3-29 is a small non-coding RNA that is expressed in various tissues of the human body. It is a member of the IGHV family and is involved in the regulation of various cellular processes, including the immune response. Further research is needed to fully understand the role of IGHV3-29 in the immune system and its potential as a drug target or biomarker.

Protein Name: Immunoglobulin Heavy Variable 3-29 (pseudogene)

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