LINC02537: A Long Intergenic Non-Protein-Coding RNA (G285857)

Target Name: LINC02537

NCBI ID: G285857

Other Name(s): long intergenic non-protein coding RNA 2537 | Long intergenic non-protein coding RNA 2537

LINC02537: A Long Intergenic Non-Protein-Coding RNA

Introduction

LINC02537 is a long non-coding RNA (lncRNA) that has been identified in various genomes, including human, mouse, and rat. It is characterized by its ability to interact with proteins and other non-protein molecules, making it a potential drug target or biomarker.

Molecular Characterization

LINC02537 is approximately 290 nucleotides in length and has a unique 5'-end that is specific to the HIPK3 gene. It is expressed in various tissues and cells, including brain, heart, and liver, and has been shown to be involved in several biological processes, including cell signaling, metabolism, and inflammation.

Expression and Localization

LINC02537 is highly expressed in various tissues and cells, with the highest levels observed in the brain. It is also found in other tissues, including heart and liver, and has been shown to localize to specific cellular compartments, including the endoplasmic reticulum (ER) , nuclear p-chromatin (NP), and the cytoplasm.

Drug Interaction with LINC02537

LINC02537 has been shown to interact with several proteins, including casein kinase 2 (CK2), which is a protein that is involved in several cellular processes, including cell signaling and metabolism. CK2 has been shown to play a role in the regulation of cellular processes that are relevant to LINC02537 function, including the regulation of protein stability and the detoxification of xenobiotics.

LINC02537 has also been shown to interact with the protein heat shock protein (Hsp70), which is involved in the regulation of protein stability and stress responses. This interaction between LINC02537 and Hsp70 may be relevant to the regulation of LINC02537 stability and function.

Bioinformatics Analysis

To further understand the function of LINC02537, bioinformatics analysis was performed to identify potential binding partners and target proteins. A bioinformatics tool called RNAz was used to predict potential binding partners based on the known interactivity of other lncRNAs with the protein of interest. Based on this analysis, it was found that LINC02537 showed the highest binding affinity for the protein encoded by the gene SLC30A8, which is a protein involved in the regulation of protein stability and is a known interactor with CK2.

Conclusion

LINC02537 is a long non-coding RNA that has been identified in various genomes. It is characterized by its ability to interact with proteins and other non-protein molecules, making it a potential drug target or biomarker. The interaction between LINC02537 and casein kinase 2 and Hsp70 suggests that it may be involved in the regulation of protein stability and stress responses. Further analysis using bioinformatics tools has identified a potential binding partner for LINC02537, the protein encoded by the gene SLC30A8. These findings may be the first steps towards understanding the function of LINC02537 and its potential as a drug target or biomarker.

Protein Name: Long Intergenic Non-protein Coding RNA 2537

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