LINC00221: A Long Intergenic Non-Protein-Coding RNA as a Drug Target and Biomarker

Target Name: LINC00221

NCBI ID: G338005

Other Name(s): long intergenic non-protein coding RNA 221 | Chromosome 14 open reading frame 98 | C14orf98 | Long intergenic non-protein coding RNA 221 | NCRNA00221

LINC00221: A Long Intergenic Non-Protein-Coding RNA as a Drug Target and Biomarker

LINC00221 is a long non-coding RNA (lncRNA) that has been identified in various organisms, including humans. It has a unique feature of being located between the coding regions of two closely related proteins, ZNF2 and NF217, which encode for the transcription factor p53 and the protein ZNF217, respectively. ZNF2 and NF217 are involved in the regulation of cell growth, apoptosis, and survival, and LINC00221 has been implicated in these processes.

Drug Target Potential

LINC00221 has been identified as a potential drug target due to its involvement in cell growth and apoptosis. It has been shown to play a role in the regulation of cell cycle progression, apoptosis, and survival. LINC00221 has been shown to interact with various protein kinases, including Src, FAK, and PDGFR. These interactions suggest that LINC00221 may be a useful target for small molecule inhibitors of protein kinases that are involved in cell growth and survival.

Biomarker Potential

LINC00221 has also been identified as a potential biomarker for various diseases, including cancer. Its expression has been shown to be elevated in various types of cancer, including breast, ovarian, and colorectal cancer. This suggests that LINC00221 may be a useful biomarker for the diagnosis and treatment of these diseases.

Expression and Functions

LINC00221 has been shown to have various functions in various organisms, including its role in cell growth and apoptosis. It has been shown to be involved in the regulation of cell cycle progression, apoptosis, and survival. LINC00221 has been shown to interact with various protein kinases, including Src, FAK, and PDGFR. These interactions suggest that LINC00221 may be a useful target for small molecule inhibitors of protein kinases that are involved in cell growth and survival.

Conclusion

In conclusion, LINC00221 is a long non-coding RNA that has been identified in various organisms, including humans. It has unique features, such as being located between the coding regions of two closely related proteins, ZNF2 and NF217. LINC00221 has been shown to play a role in the regulation of cell cycle progression, apoptosis, and survival, and has potential as a drug target and biomarker. Further research is needed to fully understand the functions and potential applications of LINC00221.

Protein Name: Long Intergenic Non-protein Coding RNA 221

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