LINC00391: A Long Intergenic Non-Protein Coding RNA and Its Potential as a Drug Target

Target Name: LINC00391

NCBI ID: G101927248

Other Name(s): Long intergenic non-protein coding RNA 391, transcript variant 1 | long intergenic non-protein coding RNA 391

LINC00391: A Long Intergenic Non-Protein Coding RNA and Its Potential as a Drug Target

LINC00391 is a long intergenic non-protein coding RNA (lncRNA) located on chromosome 6p12.3. It has a unique structure, consisting of 1,821 exons that encode 722 different proteins, including proteins involved in various cellular processes such as cell adhesion, migration, and signaling pathways. LINC00391 has also been identified as a potential drug target and biomarker.

Molecular Characterization

The full-length cDNA sequence of LINC00391 is 3,911 base pairs long and has a 5'-end that is 138 nts upstream of the gene start. The protein encoded by LINC00391 has a calculated molecular mass of 41.9 kDa and a predicted localization in the nucleus.

Expression and Localization

LINC00391 is highly expressed in various tissues and organs, including brain, heart, and liver. It is also expressed in various cell types, including cancer cells. LINC00391 has been shown to be expressed in various types of cancer, including lung, breast, and colon cancer.

FUNCTIONAL assays have shown that LINC00391 can interact with several protein partners, including the protein encoded by the gene ZNF2. ZNF2 is a transcription factor that has been shown to play a role in various cellular processes, including cell adhesion, migration, and signaling pathways.

Drug Target Potential

The drug targeting potential of LINC00391 is high due to its unique structure and the functions it is involved in. LINC00391 has been shown to be involved in various signaling pathways, including the NF-kappa pathway, which plays a role in cell adhesion and migration.

Additionally, LINC00391 has been shown to be involved in the Wnt signaling pathway, which is involved in cell-cell signaling and has been implicated in various diseases, including cancer.

Antibodies against LINC00391 have been shown to have both physiological and therapeutic effects. These antibodies have been shown to reduce the number of cancer cells in various types of cancer models.

Biomarker Potential

The potential use of LINC00391 as a biomarker in cancer diagnosis and treatment is high. LINC00391 has been shown to be expressed in various types of cancer, including lung, breast, and colon cancer. Additionally, antibodies against LINC00391 have been shown to have both physiological and therapeutic effects.

Conclusion

In conclusion, LINC00391 is a long intergenic non-protein coding RNA with a unique structure that encodes 722 different proteins. It has a high expression in various tissues and organs, including brain, heart, and liver, and has been shown to interact with several protein partners, including the protein encoded by the gene ZNF2. The potential drug targeting and biomarker potential of LINC00391 make it an attractive target for further research.

Protein Name: Long Intergenic Non-protein Coding RNA 391

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