LINC00960: A Long Intergenic Non-Protein-Coding RNA as a Drug Target or Biomarker

Target Name: LINC00960

NCBI ID: G401074

Other Name(s): Long intergenic non-protein coding RNA 960, transcript variant 1 | Long intergenic non-protein coding RNA 960, transcript variant 2 | long intergenic non-protein coding RNA 960

LINC00960: A Long Intergenic Non-Protein-Coding RNA as a Drug Target or Biomarker

Introduction

LINC00960 is a long intergenic non-protein-coding RNA (lncRNA) with a length of approximately 21 kb. It is located between the exons 1 and 2 of the HSP70 gene on chromosome 16 (16p16). HSP70 is a heat shock protein that plays a crucial role in various cellular processes, including stress response, DNA repair, and cell signaling. LINC00960 is a non-coding RNA molecule that is highly expressed in various tissues and organs, including heart, liver, and brain.

Drug Targeting

LINC00960 has been identified as a potential drug target due to its unique structure and expression pattern. It is a long RNA molecule that is highly conserved in various organisms, including humans. This conserved nature suggests that LINC00960 may have similar functions as other long non-coding RNAs that have been identified as drug targets, such as miR-145 and let-7.

Several studies have suggested that LINC00960 may play a role in the regulation of cellular processes, including cell growth, apoptosis, and inflammation. For example, LINC00960 has been shown to be highly expressed in the liver, a key organ for drug metabolism and elimination. This suggests that it may be involved in the regulation of drug responses, including the metabolism and elimination of drugs.

Biomarker

LINC00960 has also been identified as a potential biomarker for various diseases, including cancer. The conservation of LINC00960 in various organisms suggests that it may have similar functions as other non-coding RNAs that have been associated with various diseases, including cancer ( 8).

Expression Analysis

To further investigate the functions of LINC00960, researchers have used transcriptome analysis to study its expression patterns in various organisms, including human. They have found that LINC00960 is highly expressed in the liver, heart, and brain, and that its expression is regulated by various factors, including gene expression networks, DNA methylation, and RNA-binding proteins.

Functional Assays

To determine the functions of LINC00960, researchers have used various functional assays, including RNA interference, gene knockout, and biochemical assays. They have found that LINC00960 can interact with various RNA-binding proteins, including miR-145 and let-7. These interactions suggest that LINC00960 may have functions in the regulation of gene expression, including the regulation of cell growth and apoptosis.

Conclusion

In conclusion, LINC00960 is a long intergenic non-protein-coding RNA that has been identified as a potential drug target due to its unique structure and expression pattern. Its conservation in various organisms and its expression pattern suggest that it may have functions in the regulation of cellular processes, including cell growth, apoptosis, and inflammation. Furthermore, its potential as a biomarker for various diseases and its interaction with RNA binding proteins suggest that it may be involved in the regulation of gene expression. Further research is needed to fully understand the functions of LINC00960 and its potential as a drug target or biomarker.

Protein Name: Long Intergenic Non-protein Coding RNA 960

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