Target Name: MINK1
NCBI ID: G50488
Other Name(s): GCK family kinase MiNK | Mitogen-activated protein kinase kinase kinase kinase 6 | Misshapen-like kinase 1 (isoform 3) | Misshapen/NIK-related kinase | MAP4K6 | Misshapen like kinase 1, transcript variant 3 | B55 | misshapen like kinase 1 | Misshapen-like kinase 1 (isoform 5) | MEK kinase kinase 6 | hMINK | MINK1 variant 5 | MINK1 variant 3 | MEKKK 6 | GCK family kinase MINK | MGC21111 | MINK | YSK2 | misshapen/NIK-related kinase | Misshapen like kinase 1, transcript variant 5 | Serine/threonine protein kinase | MINK1_HUMAN | MAPK/ERK kinase kinase kinase 6 | mitogen-activated protein kinase kinase kinase kinase 6 | hMINKbeta | ZC3 | Misshapen-like kinase 1

MINK1: A Protein Involved in Cell Signaling and Tissue Development

MINK1 (Minkin kinase 1) is a protein that is expressed in various tissues and cell types throughout the body. It is a member of the GCK family of kinases, which are known for their role in cell signaling and metabolism. MINK1 has been shown to play a role in a variety of cellular processes, including cell growth, differentiation, and survival.

One of the key functions of MINK1 is its role in cell signaling. MINK1 is involved in the regulation of several different signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. These pathways are involved in a wide range of cellular processes, including cell growth, differentiation, and survival.

MINK1 is also involved in the regulation of cellular processes that are important for tissue development and maintenance. For example, MINK1 has been shown to play a role in the regulation of cell proliferation and the development of tissues such as neural tissue, muscle tissue, and epithelial tissue.

In addition to its role in cell signaling and tissue development, MINK1 is also involved in the regulation of cellular processes that are important for the immune system. MINK1 has been shown to play a role in the regulation of T cell development and function, and it is thought to be involved in the regulation of immune cell survival.

MINK1 is also a potential drug target. Several studies have shown that MINK1 can be inhibited by small molecules, and that this inhibition can have a variety of different effects on cellular processes. For example, one study found that inhibition of MINK1 led to the growth arrest and apoptosis of cancer cells, while another study found that inhibition of MINK1 led to the inhibition of cancer cell migration.

In addition to its potential as a drug target, MINK1 is also a potential biomarker. Several studies have shown that MINK1 can be used as a biomarker for a variety of different diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. For example, one study found that MINK1 was overexpressed in neurodegenerative diseases, while another study found that MINK1 was overexpressed in cancer cells.

Overall, MINK1 is a protein that is involved in a wide range of cellular processes and is a potential drug target and biomarker. Further research is needed to fully understand the role of MINK1 in cellular processes and its potential as a drug and biomarker.

Protein Name: Misshapen Like Kinase 1

Functions: Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1

More Common Targets

MINPP1 | MIOS | MIOX | MIP | MIPEP | MIPEPP3 | MIPOL1 | MIR1-1 | MIR1-1HG | MIR1-2 | MIR100 | MIR100HG | MIR101-1 | MIR101-2 | MIR10394 | MIR10396B | MIR10399 | MIR103A1 | MIR103A2 | MIR103B1 | MIR103B2 | MIR105-1 | MIR105-2 | MIR10527 | MIR106A | MIR106B | MIR107 | MIR10A | MIR10B | MIR11181 | MIR11400 | MIR11401 | MIR1178 | MIR1179 | MIR1180 | MIR1181 | MIR1182 | MIR1183 | MIR1184-1 | MIR1184-2 | MIR1184-3 | MIR1185-1 | MIR1185-2 | MIR1193 | MIR1197 | MIR1199 | MIR1200 | MIR1202 | MIR1203 | MIR1204 | MIR1205 | MIR1206 | MIR1207 | MIR1208 | MIR12129 | MIR12135 | MIR12136 | MIR122 | MIR1224 | MIR1225 | MIR1226 | MIR1227 | MIR1228 | MIR1229 | MIR1231 | MIR1233-1 | MIR1233-2 | MIR1234 | MIR1236 | MIR1237 | MIR1238 | MIR124-1 | MIR124-1HG | MIR124-2 | MIR124-2HG | MIR124-3 | MIR1243 | MIR1244-1 | MIR1244-2 | MIR1244-3 | MIR1245A | MIR1245B | MIR1246 | MIR1247 | MIR1248 | MIR1249 | MIR1250 | MIR1251 | MIR1252 | MIR1253 | MIR1254 | MIR1255A | MIR1255B1 | MIR1255B2 | MIR1256 | MIR1257 | MIR1258 | MIR125A | MIR125B1 | MIR125B2