PCDHA8: A Potential Drug Target and Biomarker (G56140)

Target Name: PCDHA8

NCBI ID: G56140

PCDHA8: A Potential Drug Target and Biomarker

PCDH伪8 (PCDH-alpha-8) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for various diseases, including cancer. PCDH伪8 plays a crucial role in the regulation of cell proliferation and has been implicated in the development and progression of various diseases.

The PCDH伪8 gene, which encodes a 22-kDa protein, is located on chromosome 6p11.2 and has been annotated as a potential gene for cancer-related diseases. Several studies have suggested that PCDH伪8 may be involved in the regulation of cell proliferation, apoptosis , and angiogenesis, which are critical processes in the development and progression of cancer.

PCDH伪8 has been shown to be expressed in various tissues and cancer types, including brain, breast, lung, and colon cancer. It has also been found to be associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key functions of PCDH伪8 is its role in cell proliferation. Several studies have shown that PCDH伪8 plays a negative role in cell proliferation, by regulating the activity of the oncogene transforming growth factor-beta (TGF-β). TGF-β is a well-known transcription factor that promotes cell proliferation and is often involved in the development and progression of cancer.

In addition to its role in cell proliferation, PCDH伪8 has also been shown to play a key role in apoptosis, which is the process by which cells die and are removed from the body. Several studies have shown that PCDH伪8 is involved in the regulation of apoptosis , by activating the B-cell maturation antigen (BMA) gene. BMA is a transmembrane protein that is involved in the regulation of apoptosis, and its levels have been shown to be regulated by PCDH伪8.

PCDH伪8 has also been shown to be involved in the regulation of angiogenesis, which is the process by which new blood vessels form in the body. Several studies have shown that PCDH伪8 plays a negative role in angiogenesis, by regulating the activity of the vascular endothelial growth factor (VEGF) gene. VEGF is a transmembrane protein that is involved in the regulation of angiogenesis, and its levels have been shown to be regulated by PCDH伪8.

In conclusion, PCDH伪8 is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for various diseases, including cancer. Its role in cell proliferation, apoptosis, and angiogenesis, as well as its association with various diseases, make it an attractive target for future research. Further studies are needed to determine the full extent of PCDH伪8's involvement in disease and to develop effective strategies for targeting this potential drug target.

Protein Name: Protocadherin Alpha 8

Functions: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

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