PSMD12: A Potential Drug Target and Biomarker for Proteasome-Mediated Diseases

Target Name: PSMD12

NCBI ID: G5718

PSMD12: A Potential Drug Target and Biomarker for Proteasome-Mediated Diseases

Introduction

Proteasomes are key intracellular protein structures that play a crucial role in regulating various cellular processes. The 26S subunit of the proteasome, also known as PSMD12, is a non-ATPase protein that functions as a key regulator of the proteasome's integrity and function [1, 2]. In this article, we will discuss PSMD12 as a potential drug target and biomarker for various proteasome-mediated diseases.

PSMD12 as a Drug Target

PSMD12 has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. PSMD12 is a 12kDa protein that contains a single transmembrane domain and a N-terminus that contains a benzimidazole ring structure. This structural feature makes PSMD12 a potential target for small molecules, antibodies, or other therapeutic agents that can interact with the protein and modulate its function.

PSMD12 has been shown to play a critical role in regulating the activity of the proteasome in various cellular processes. For example, PSMD12 has been shown to interact with the nucleotide-binding oligomerization domain (N-BOD) of the protasome, which is responsible for regulating the assembly and disassembly of the proteasome [4,5]. The N-BOD domain is a key regulatory domain that contains a nucleotide-binding site, which allows the protein to interact with various nucleotides and regulate the activity of the proteasome.

In addition to its involvement in regulating the proteasome, PSMD12 has also been shown to play a critical role in the regulation of various cellular processes, including cell growth, apoptosis, and inflammation [6,7]. For example, PSMD12 has been shown to be involved in the regulation of cell cycle progression, and its knockdown has been shown to result in increased cell cycle progression and a higher risk of cancer [8,9].

PSMD12 has also been shown to play a critical role in the regulation of inflammation and cellular immune responses. For example, PSMD12 has been shown to be involved in the regulation of the production of pro-inflammatory cytokines, such as TNF-伪, and its knockdown has been shown to reduce the production of these cytokines [10,11].

PSMD12 as a Biomarker

PSMD12 has also been shown to be a potential biomarker for various proteasome-mediated diseases. The loss of PSMD12 has been observed in various diseases, including neurodegenerative disorders, cancer, and autoimmune diseases [12,13].

For example, studies have shown that individuals with certain genetic mutations, such as those in the PSMD12 gene, are at increased risk for developing neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease [14,15]. The loss of PSMD12 has been observed in individuals with these genetic mutations, and its expression has been shown to be decreased in the brains of individuals with these disorders [14,15].

PSMD12 has also been shown to be involved in the regulation of cancer progression. For example, studies have shown that PSMD12 has been involved in the regulation of cancer cell survival and angiogenesis [16,17]. The loss of PSMD12 has been observed in various types of cancer, and its expression has been shown to be decreased in the tumors of individuals with these conditions [16,17].

PSMD12 has also been shown to be involved in the regulation of autoimmune diseases. For example, studies have shown that PSMD12 has

Protein Name: Proteasome 26S Subunit, Non-ATPase 12

Functions: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair

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