Understanding ACTB: Potential Drug Targets (G60)

Target Name: ACTB

NCBI ID: G60

Understanding ACTB: Potential Drug Targets

ACTB (Beta-actin) is a protein that is expressed in various tissues throughout the body, including muscle, heart, and brain. It is a key component of the cytoskeleton, which is the structure that gives cells their shape and supports their mechanical forces. In addition to its role in cytoskeleton organization, ACTB is also involved in various cellular processes that are essential for cell survival and proper function.

Drug Targets and Biomarkers

ACTB has been identified as a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and various functions make it an attractive target for small molecule inhibitors.

One of the main reasons for the interest in ACTB as a drug target is its involvement in cell signaling pathways. ACTB is a key component of the cytoskeleton, and it plays a role in the regulation of cell cytoskeleton dynamics and stability. This involves the interaction between ACTB and various signaling pathways, including TGF-β, Wnt, and Hedgehog.

In addition to its role in signaling pathways, ACTB is also involved in the regulation of cellular processes that are critical for cell survival. For example, ACTB is involved in the regulation of cell adhesion, which is critical for the development and maintenance of tissues and organs. It also plays a role in the regulation of cell migration, which is essential for the formation of tissues and organs during development.

In conclusion, ACTB is a protein that is involved in various cellular processes that are critical for cell survival and proper function. Its unique structure and various functions make it an attractive target for small molecule inhibitors. Further research is needed to fully understand the role of ACTB as a drug target and its potential therapeutic applications.

Protein Name: Actin Beta

Functions: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)

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