Understanding CD47: A Potential Drug Target and Biomarker (G64084)

Target Name: CLSTN2

NCBI ID: G64084

Understanding CD47: A Potential Drug Target and Biomarker

CLSTN2 (CSTN2_HUMAN), a gene encoding a protein known as CD47, is a protein that is expressed in various tissues throughout the human body, including the bone marrow, spleen, and blood cells. CD47 is a type of antigen receptor that is found on the surface of hematopoietic stem cells, which are responsible for the production of all of the different types of blood cells in the body.

CD47 is also expressed in other tissues and cells, including the skin, gut, and nervous system. Its function is not well understood, but it is believed to play a role in the immune response and the development of certain diseases.

One of the things that makes CD47 an attractive drug target is its expression in a wide range of tissues, which makes it less likely to have unintended consequences when used to treat a specific disease. Additionally, its function in the immune response makes it a potential target for drugs that are designed to modulate the immune system.

CD47 is also a potential biomarker for certain diseases. For example, high levels of CD47 have been observed in patients with acute myeloid leukemia, a type of cancer that affects the bone marrow and blood cells. Additionally, studies have shown that CD47 levels are elevated in patients with multiple myeloma, another type of cancer that affects the bone marrow.

Despite the potential benefits of CD47 as a drug target and biomarker, more research is needed to fully understand its function and potential applications. One of the main challenges in studying CD47 is its complex expression in different tissues and cells. Additionally, the lack of human models of CD47 disease makes it difficult to study its effects in a controlled environment.

In conclusion, CD47 is a protein that is expressed in various tissues throughout the human body and is considered a potential drug target and biomarker. Further research is needed to fully understand its function and potential applications.

Protein Name: Calsyntenin 2

Functions: Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate synapse formation, and which is involved in learning and memory (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity)

More Common Targets