Target Name: LOC645468
NCBI ID: G645468
Other Name(s): insulin like growth factor 2 mRNA binding protein 3 pseudogene | Insulin-like growth factor 2 mRNA binding protein 3 pseudogene

LOC645468: A Potential Drug Target and Biomarker for Insulin-like Growth Factor 2 (IGF2)

Insulin-like growth factor 2 (IGF2) is a potent growth factor that regulates cellular growth, differentiation, and survival. IGF2 has been implicated in various diseases, including cancer, neurodegenerative disorders, and developmental defects. Its role in these processes makes IGF2 a promising target for therapeutic intervention. The LOC645468 gene, which encodes a protein known as insulin-like growth factor 2 mRNA binding protein 3 (IGF2MBP3), is a potential drug target and biomarker for IGF2-related diseases.

The IGF2 pathway: Driven by insulin and growth factors

The insulin-like growth factor (IGF) pathway is a complex signaling pathway that regulates cellular growth and development. The IGF pathway is characterized by the presence of several transcription factors, including insulin, growth factors, and their downstream targets. The IGF pathway is essential for the growth, differentiation, and survival of various cell types, including tissues, organs, and organs.

Insulin is a key transcription factor in the IGF pathway. It promotes the expression of genes involved in cell growth, differentiation, and survival. Insulin signaling is activated by various factors, including growth factors, which include growth factors A, B, and C (IGF-1, IGF-2, and IGF-3). These growth factors recruit specific transcription factors to their respective nuclear response elements, resulting in the expression of target genes involved in cellular growth and development.

LOC645468: A protein with potential clinical impact

The LOC645468 gene encodes a protein known as IGF2MBP3. This protein is a key component of the IGF2 signaling pathway. IGF2MBP3 functions as a protein-protein interaction (PPI) partner for the transcription factor, transforminger-1 (TXR1). IGF2MBP3 plays a crucial role in the regulation of cellular growth, differentiation, and survival, and its aberration has been implicated in various diseases.

In neurodegenerative disorders, IGF2MBP3 has been implicated in the development and progression of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. In cancer, IGF2MBP3 has been associated with the regulation of cell cycle progression and the maintenance of stem-like characteristics.

As a potential drug target, IGF2MBP3 can be targeted with small molecules or antibodies to modulate its activity and improve therapeutic outcomes in neurodegenerative disorders and cancer. Additionally, IGF2MBP3 levels have been suggested as a potential biomarker for the diagnosis and prognosis of various diseases.

Conclusion

LOC645468 is a gene that encodes a protein involved in the insulin-like growth factor (IGF) pathway. This protein has potential clinical impact as a drug target and biomarker for IGF2-related diseases. The identification of LOC645468 as a potential drug target and biomarker opens up new avenues for the development of therapeutic interventions aimed at improving the lives of patients with neurodegenerative disorders and cancer.

Targeting IGF2MBP3 with small molecules or antibodies may offer promising results in modulating its activity and improving therapeutic outcomes in IGF2-related diseases. Further research is needed to determine the efficacy and safety of these approaches, as well as to explore the potential implications of LOC645468 as a biomarker for IGF2-related diseases.

Protein Name: Insulin Like Growth Factor 2 MRNA Binding Protein 3 Pseudogene

More Common Targets

LOC645503 | LOC645967 | LOC646044 | LOC646214 | LOC646358 | LOC646471 | LOC646674 | LOC646736 | LOC646762 | LOC646813 | LOC646836 | LOC646853 | LOC646903 | LOC646934 | LOC646970 | LOC647115 | LOC647132 | LOC647481 | LOC649133 | LOC650157 | LOC650226 | LOC651536 | LOC652276 | LOC652608 | LOC653303 | LOC653503 | LOC653513 | LOC653631 | LOC653653 | LOC653698 | LOC727751 | LOC728024 | LOC728098 | LOC728114 | LOC728138 | LOC728376 | LOC728392 | LOC728417 | LOC728485 | LOC728554 | LOC728660 | LOC728688 | LOC728715 | LOC728739 | LOC728743 | LOC728877 | LOC728989 | LOC729086 | LOC729164 | LOC729173 | LOC729218 | LOC729296 | LOC729444 | LOC729609 | LOC729683 | LOC729732 | LOC729737 | LOC729815 | LOC729870 | LOC729887 | LOC729966 | LOC729973 | LOC730098 | LOC730100 | LOC730101 | LOC730183 | LOC730234 | LOC730338 | LOC730668 | LOC90246 | LOC91450 | LOC93429 | LOC93463 | LOC93622 | LOH12CR2 | Long intergenic non-protein coding RNA 1336 | Long intergenic non-protein coding RNA 205 | Long intergenic non-protein coding RNA 266-4, pseudogene | Long-chain-fatty-acid--CoA ligase | LONP1 | LONP2 | LONRF1 | LONRF2 | LONRF3 | LORICRIN | LOX | LOXHD1 | LOXL1 | LOXL1-AS1 | LOXL2 | LOXL3 | LOXL4 | LPA | LPAL2 | LPAR1 | LPAR2 | LPAR3 | LPAR4 | LPAR5 | LPAR6