ANTKMT: A Potential Drug Target for Cancer (G65990)

Target Name: ANTKMT

NCBI ID: G65990

ANTKMT: A Potential Drug Target for Cancer

ANTKMT (Adenine nucleotide translocase lysine N-methyltransferase) is a gene that encodes a protein involved in DNA methylation. Specifically, ANTKMT is responsible for the transfer of adenine nucleotides to the 5' end of a linear DNA molecule. This process is critical for the regulation of gene expression and is a target of interest in the field of cancer.

In cancer, abnormal methylation of gene promoters can lead to the activation of oncogenes and the inhibition of tumor suppressor genes. This process can result in the development of a variety of diseases, including cancer. Therefore, the study of ANTKMT and its role in DNA methylation regulation is of great importance in the understanding of cancer biology.

ANTKMT is a key enzyme in the DNA methylation pathway. It is responsible for the transfer of adenine nucleotides to the 5' end of a linear DNA molecule. This process is critical for the regulation of gene expression and is a target of interest in the field of cancer.

ANTKMT is a protein that is expressed in a variety of tissues, including muscle, pancreas, and testes. It is also highly expressed in cancer tissues, including breast cancer, lung cancer, and colorectal cancer. This suggests that ANTKMT may be a useful biomarker for the diagnosis and treatment of cancer.

ANTKMT is a potential drug target in cancer. By inhibiting the activity of ANTKMT, doctors may be able to turn off the activity of oncogenes and tumor suppressor genes. This could lead to the regression of cancer tumors. Additionally, ANTKMT may also be a useful target for cancer therapies that target the DNA methylation pathway.

In conclusion, ANTKMT is a gene that is involved in the regulation of DNA methylation. It is a potential drug target in cancer and may be useful for the diagnosis and treatment of cancer. Further research is needed to fully understand the role of ANTKMT in DNA methylation regulation and its potential as a drug target.

Protein Name: Adenine Nucleotide Translocase Lysine Methyltransferase

Functions: Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration (PubMed:31213526). Probably also trimethylates ANT1/SLC25A4 (PubMed:31213526)

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