D2HGDH: A Potential Drug Or Biomarker (G728294)

Target Name: D2HGDH

NCBI ID: G728294

D2HGDH: A Potential Drug Or Biomarker

D2HGDH (Dihydroorotate Hydrotransferase) is a protein that is expressed in various tissues throughout the body. It is a member of the superfamily of ATP-binding proteins, which are a group of enzymes that use ATP to regulate various cellular processes. One of the functions of D2HGDH is to regulate the production of adenosine, a molecule that plays a crucial role in signaling throughout the body.

D2HGDH is also involved in the regulation of the levels of calcium in the body. It is a critical enzyme in the regulation of calcium homeostasis, which is essential for many cellular processes, including muscle contractions, nerve function, and blood clotting.

In addition to its role in calcium homeostasis, D2HGDH is also involved in the regulation of many other cellular processes. It is an enzyme that is involved in the regulation of cell adhesion, which is the process by which cells stick together to form tissues and organs. D2HGDH is also involved in the regulation of cell signaling, as well as the regulation of cellular uptake and release of various signaling molecules.

D2HGDH is a protein that is expressed in many different tissues throughout the body, including the brain, heart, kidneys, and intestine. It is also expressed in various cell types, including muscle cells, nerve cells, and blood cells.

One of the potential benefits of targeting D2HGDH as a drug or biomarker is that it has been shown to have a wide range of potential therapeutic applications. For example, studies have shown that D2HGDH is involved in the regulation of many important cellular processes, and that it can be used to treat a variety of conditions.

In addition to its potential therapeutic applications, D2HGDH is also a promising biomarker for a variety of diseases. For example, studies have shown that D2HGDH is often reduced in the blood of people with a variety of diseases, including heart disease, diabetes, and cancer. This suggests that D2HGDH may be a useful biomarker for these diseases, and that targeting it as a drug could be an effective way to diagnose and treat them.

Overall, D2HGDH is a protein that is involved in a wide range of cellular processes and has the potential to be a drug or biomarker. Further research is needed to fully understand its role in the regulation of these processes and its potential therapeutic applications.

Protein Name: D-2-hydroxyglutarate Dehydrogenase

Functions: Catalyzes the oxidation of D-2-hydroxyglutarate (D-2-HG) to alpha-ketoglutarate (PubMed:15070399, PubMed:15609246, PubMed:16037974, PubMed:20020533, PubMed:33431826). Also catalyzes the oxidation of other D-2-hydroxyacids, such as D-malate (D-MAL) and D-lactate (D-LAC) (PubMed:33431826). Exhibits high activities towards D-2-HG and D-MAL but a very weak activity towards D-LAC (PubMed:33431826)

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